Transcutaneous neuroadaptive electrical stimulation for treatment of uncontrolled asthma
https://doi.org/10.18093/0869-0189-2013-0-2-52-56
Abstract
Summary. Fifty five patients with severe uncontrolled asthma were randomly assigned to treatment with standard therapy alone (n = 25) or standard therapy combined with transcutaneous neuroadaptive electrical stimulation (n = 30). Twenty healthy volunteers were as controls. Structural and functional disorders of the erythrocyte membrane were shown to play a crucial role in the pathogenesis of severe hypoxia typical for this disease. These disorders could be due to hypoxic hyperactivity of lipid peroxidation of membrane phospholipids. The transcutaneous neuroadaptive electrical stimulation reduced severity of the cell oxidative stress, the erythrocyte membrane injury and hypoxia that resulted in improvement in clinical and functional parameters of asthma. Among the patients treated with the transcutaneous neuroadaptive electrical stimulation, good control of asthma was achieved in 17 patients (56.7 %) and partial control was achieved in 10 patients (33.3 %) compared to 13 (52 %) patients and 9 (36 %) patients, respectively, in the standard therapy group.
About the Authors
M. A. Abdullaeva
ФГБУ "Научно-исследовательский институт пульмонологии" ФМБА России; ФГБУ науки "Институт теоретической и экспериментальной биофизики РАН"
Russian Federation
Russian Federation
E. Kh. Anaev
ФГБУ "Научно-исследовательский институт пульмонологии" ФМБА России
Russian Federation
Russian Federation
N. B. Karmen
ФГБУ науки "Институт теоретической и экспериментальной биофизики РАН"
Russian Federation
Russian Federation
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For citations:
Abdullaeva M.A., Anaev E.Kh., Karmen N.B. Transcutaneous neuroadaptive electrical stimulation for treatment of uncontrolled asthma. PULMONOLOGIYA. 2013;(2):52-56. (In Russ.) https://doi.org/10.18093/0869-0189-2013-0-2-52-56
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