Exercise induced bronchoconstriction and expiratory nitric oxide level in winter sports athletes
https://doi.org/10.18093/0869-0189-2012-0-1-61-65
Abstract
Summary. Currently, there are no data available regarding relationship between exhaled nitric oxide and lung function in adolescent and young adult elite athletes. Eighty six adolescent and young adult elite athletes of winter sports were included in this study. Pulmonary function and exhaled NO level were measured before and after standard exercise with treadmill. Post-exercise 10 % reduction in FEV1 was registered in 21 % of athletes. Exhaled NO level was higher in males (p = 0.04). Gender differences in changes of exhaled NO after the exercise were determined (–10.6 % in males and 28.3 % in females). Correlations between exhaled NO level and pulmonary function were firstly described.
About the Authors
L. Yu. NikitinaRussian Federation
S. Sh. Gasymova
Russian Federation
A. A. Ulyanov
Russian Federation
T. V. Shashkova
Russian Federation
Yu. A. Petrovskaya
Russian Federation
F. I. Petrovsky
Russian Federation
References
1. Rundell K.W., Slee J.B. Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes. J. Allergy Clin. Immunol. 2008; 122 (2): 238–246.
2. Anderson S.D., Daviskas E. The mechanism of exerciseinduced asthma is. J. Allergy Clin. Immunol. 2000; 106: 453–459.
3. Fitch K.D., Sue-Chu M., Anderson S.D. et al. Asthma and the elite athlete: summary of the International Olympic Committee's Consensus Conference, Lausanne, Switzerland, January 22–24, 2008. J. Allergy Clin. Immunol. 2008; 122: 254–260.
4. Anderson S.D., Schoeffel R.E., Follet R. et al. Sensitivity to heat and water loss at rest and during exercise in asthmatic patients. Eur. J. Respir. Dis. 1982; 63: 459–471.
5. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention [Электронный ресурс]. – Электрон. дан. 2010.
6. Tilemanna L., Gindnerb L., Meyerc F. Differences in local and systemic inflammatory markers in patients with obstructive airways disease. Prim. Care Respir. J. 2011; 20 (4): 407–413.
7. Sue-Chu M., Henriksen A.H., Bjermer L. Non-invasive evaluation of lower airway inflammation in hyper-responsive elite cross-country skiers and asthmatics. Respir. Med. 1999; 93 (10): 719–725.
8. Guidelines for methacholine and exercise challenge testing, American Thoracic Society, 1999. Am. J. Respir. Crit. Care Med. 2000; 161 (1): 309–29.
9. ATS / ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am. J. Respir. Crit. Care Med. 2005; 171 (8): 912–930.
10. Scollo M., Zanconato S., Ongaro R. et al. Exhaled nitric oxide and exercise-induced bronchoconstriction in asthmatic children. Am. J. Respir. Crit. Care Med. 1999; 160: 1047–1050.
11. Terada A., Fujisawa T., Togashi K. et al. Exhaled nitric oxide decreases during exercise-induced bronchoconstriction in children with asthma. Am. J. Respir. Crit. Care Med. 2001; 164: 1879–1884.
12. Kotaru C., Coreno A., Skowronski M. et al. Exhaled nitric oxide and thermally induced asthma. Am. J. Respir. Crit. Care Med. 2001; 163: 383–388.
13. El-Halawani S.M., Ly N.T., Mahon R.T. et al. Exhaled nitric oxide as a predictor of exercise-induced bronchoconstriction. Chest 2003; 124: 639–643.
14. Barnes P.J., Dweik R.A., Gelb A.F. A comprehensive review: exhaled nitric oxide in pulmonary diseases. Chest 2010; 138: 682–692.
15. Соодаева С.К., Климанов И.А. Нарушения окислительного метаболизма при заболеваниях респираторного тракта и современные подходы к антиоксидантной терапии. Атмосфера. Пульмонол. и аллергол. 2009; 1: 34–38.
16. Савельева М.И., Цой А.Н. Физические нагрузки, спорт и гиперреактивность бронхов. Consilium Medicum 2009; 11 (3): 37–43.
17. Wang X., Barber D. A., Lewis D. A. et al. Gender and transcriptional regulation of NO synthase and ET-1 in porcine aortic endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 1997; 273: 1962–1967.
Review
For citations:
Nikitina L.Yu., Gasymova S.Sh., Ulyanov A.A., Shashkova T.V., Petrovskaya Yu.A., Petrovsky F.I. Exercise induced bronchoconstriction and expiratory nitric oxide level in winter sports athletes. PULMONOLOGIYA. 2012;(1):61-65. (In Russ.) https://doi.org/10.18093/0869-0189-2012-0-1-61-65