Study of oxidative stress parameters in patients with chronic obstructive pulmonary disease exacerbation

The purpose of the study was to perform comparative assessment of circulating diene conjugant (DC, rel. u.) and Schiff's bases (SB, rel. u.) levels, intensity of chemiluminescence (I_max, rel. lum. u.) in serum and antioxidant activity (AOA) in patients with chronic obstructive pulmonary disease (COPD) exacerbation taking into consideration broncho-obstructive disorder severity.

Materials and Methods. Patients (n = 119; mean age – 62.0 ± 4.8 years) with COPD were studied. Forced expiratory volume in 1st second (FEV₁) in subjects, randomized in group 1 (n = 31), was ³ 80%, in group 2 (n = 43) – 79-50%, in group 3 (n = 45) – < 49%. The control group (n = 21) comprised of healthy non-smoking volunteers of matching age.

Results. It was established that changes in oxidative stress (OS) parameters in patients with COPD could be bidirectional depending on ventilation disorder severity. The level of SB was increased in association with disease severity increasing. High level of DC and I_max in all studied subjects was progressively decreased in association with increasing bronchial obstruction severity. There was 2-times increase of AOA at COPD exacerbation in patients of group 2 and significant decrease of this parameter in association with severe bronchial obstruction (FEV₁ < 49%) compared to controls.

Conclusion. The associations between levels of studied OS parameters and bronchial obstruction degree in patients with moderate and severe broncho-obstructive disorders.

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