Pulmonary mucormycosis
https://doi.org/10.18093/0869-0189-2018-28-2-243-247
Abstract
Mucormycosis (zygomicosis) is an invasive mycosis caused by fungi of the class Zygomycetes (order Mucorales). This infection could affect the lungs and has predilection for invading blood vessels resulting in generalized spreading. The disease is often difficult to diagnose. Culturing the respiratory tract samples is negative in up to 60% of patients, no reliable serologic test is available to confirm the diagnosis. Radiographic signs are similar to those of invasive aspergillosis. Therefore, the definitive diagnosis is commonly based on identification of hyphae in lung biopsy. A case of invasive mycosis caused by Zygomycetes is described in the article. This infection was diagnosed in a hospitalized patient with hepatic cirrhosis, acute pancreatic necrosis, secondary diabetes mellitus, hyperglycemia, and hepatocellular insufficiency. The clinical course of the disease was rapidly progressive. According to CT of the lungs, cavitation of pulmonary infiltrate developed in 11th day after the presentation. The diagnosis of pulmonary fungal infection was confirmed by bronchial biopsy and immunohistochemistry.
About the Authors
M. V. Samsonova
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia;
A.S.Loginov Moscow State Clinical and Research Center, Moscow Healthcare Department
Russian Federation
Doctor of Medicine, Head of Laboratory of Pathology and Immunology, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Senior Researcher, Laboratory of Pathomorphology, A.S.Loginov Moscow State Clinical and Research Center, Moscow Healthcare Department
Russian Federation
Doctor of Medicine, Head of Laboratory of Pathology and Immunology, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Senior Researcher, Laboratory of Pathomorphology, A.S.Loginov Moscow State Clinical and Research Center, Moscow Healthcare Department
A. L. Chernyayev
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia;
Federal Research Institute of Human Morphology;
N.I.Pirogov Federal Russian State National Research Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Head of Division of Basic Pulmonology, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Leading Researcher, Laboratory of Clinical Morphology, Federal Research Institute of Human Morphology; Professor, Department of Pathology and Clinical Morphology, Therapeutic Faculty, N.I.Pirogov Russian State National Research Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Head of Division of Basic Pulmonology, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Leading Researcher, Laboratory of Clinical Morphology, Federal Research Institute of Human Morphology; Professor, Department of Pathology and Clinical Morphology, Therapeutic Faculty, N.I.Pirogov Russian State National Research Medical University, Healthcare Ministry of Russia
Yu. S. Lebedin
KHEMA LLC
Russian Federation
Candidate of Medicine, Director General
Russian Federation
Candidate of Medicine, Director General
K. Yu. Mikhaylichenko
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Researcher, Laboratory of Pathology, Federal Pulmonology Research Institute
Russian Federation
Researcher, Laboratory of Pathology, Federal Pulmonology Research Institute
A. E. Polivanova
D.D.Pletnev City Teaching Hospital, Moscow Healthcare Department
Russian Federation
a physician
Russian Federation
a physician
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Review
For citations:
Samsonova M.V., Chernyayev A.L., Lebedin Yu.S., Mikhaylichenko K.Yu., Polivanova A.E. Pulmonary mucormycosis. PULMONOLOGIYA. 2018;28(2):243-247. (In Russ.) https://doi.org/10.18093/0869-0189-2018-28-2-243-247
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