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Effects of fixed combination of indacaterol/glycopyrronium in chronic obstructive pulmonary disease: state-of-the art review

https://doi.org/10.18093/0869-0189-2018-28-2-224-233

Abstract

Long-acting bronchodilators (long-acting β2-agonists (LABA), long-acting anticholinergics (LAMA) and their combinations) are the basic drugs for treatment of stable chronic obstructive pulmonary disease (COPD). Indacaterol/glycopyrronium (IND/GLY) is the first fixed LABA/LAMA combination acquired significant evidence of its efficacy for improvement lung function, symptoms, and quality of life, and decrease in the rate of acute exacerbations of COPD. The aim of this review was to reassess clinical efficacy of IND/GLY in treatment of COPD with regard to recent data and to outline the further role of this combination in therapy of COPD.

About the Authors

S. N. Avdeev
I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University); Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Doctor of Medicine, Professor, Corresponding Member of Russian Academy of Sciences, Head of Department of Pulmonology, I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University); Head of Clinical Division, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia


N. V. Trushenko
I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University); Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Candidate of Medicine, Researcher, Research Center for Monitoring and Control of Respiratory Diseases, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Assistant Lecturer, Department of Pulmonology, I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia (Sechenov University)


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Review

For citations:


Avdeev S.N., Trushenko N.V. Effects of fixed combination of indacaterol/glycopyrronium in chronic obstructive pulmonary disease: state-of-the art review. PULMONOLOGIYA. 2018;28(2):224-233. (In Russ.) https://doi.org/10.18093/0869-0189-2018-28-2-224-233

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