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A clinical case of congenital and acquired thrombophilia with pulmonary artery thrombosis

https://doi.org/10.18093/0869-0189-2017-27-3-423-426

Abstract

A clinical case of 48-year-old man with recurrent thrombosis of small pulmonary arteries (PA) has been described in the article. Hereditary and acquired thrombophilia associated with mutations of plasminogen activator inhibitor (heterozygote of the PAI-1 4G / 5G polymorphism) and platelet fibrinogen receptor (heterozygote of the ITGB3 Leu33Pro polymorphism), hyperhomocysteinemia, and hypercholesterolemia was diagnosed. The diagnosis was confirmed by measurement of blood homocysteine and cholesterol levels, and molecular investigation of gene polymorphism mentioned above. PA thrombosis and thrombus location were detected using contrast-enhanced chest computed tomography. Conservative treatment resulted in clinical and radiological improvement.

About the Authors

Sergey A. Pribylov
Kursk State Medical University, Healthcare Ministry of Russia; Kursk Regional Teaching Hospital
Russian Federation
Doctor of Medicine, Professor, Head of Department of Internal Diseases, Faculty of Postgraduate Physician Training, Kursk State Medical University, Healthcare Ministry of Russia; Deputy Director for Clinical Care, Kursk Regional Teaching Hospital; tel.: (4712) 35-32-86;


Nadezhda N. Pribylova
Kursk State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor at Department of Internal Diseases, Faculty of Postgraduate Physician Training, Kursk State Medical University, Healthcare Ministry of Russia; tel.: (4712) 35-96-15;


Oksana S. Alfimova
Kursk Regional Teaching Hospital
Russian Federation
a pneumologist at Division of Pulmonology, Kursk Regional Teaching Hospital; tel.: (951) 328-30-61;


Evgeniy A. Shabanov
Kursk State Medical University, Healthcare Ministry of Russia
Russian Federation
Candidate of Medicine, Assistant Lecturer, Department of Internal Diseases, Faculty of Postgraduate Physician Training, Kursk State Medical University, Healthcare Ministry of Russia; tel.: (910) 210-76-38;


M. Yu. Kuzichkina
Kursk State Medical University, Healthcare Ministry of Russia
Russian Federation
Postgraduate Student, Department of Internal Diseases, Faculty of Postgraduate Physician Training, Kursk State Medical University, Healthcare Ministry of Russia; tel.: (4712) 35-96-15;


References

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4. Kalashnikova E.A., Kokarovtseva S.N., Kovalenko T.F. Frequency of mutations in factor V (Leiden), prothrombin (G20210A) and 5,10-methylene tetrahydrofolate reductase (С677T) genes in Russian population. Meditsinskaya genetika. 2006; 5 (7): 27–29 (in Russian).

5. Kapustin V.M., Blinov M.N., Kargin V.D., et al. Gene determinants of hereditary thrombophilia in pathogenesis of venous thrombosis. Terapevticheskiy arkhiv. 2009; (10): 78–80 (in Russian).

6. Kirienko A.I., Panchenko E.P., Andriyashkin V.V. Venous Thrombosis in Surgical and Therapeutic Practice. Moscow: Planida; 2012 (in Russian).


Review

For citations:


Pribylov S.A., Pribylova N.N., Alfimova O.S., Shabanov E.A., Kuzichkina M.Yu. A clinical case of congenital and acquired thrombophilia with pulmonary artery thrombosis. PULMONOLOGIYA. 2017;27(3):423-426. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-3-423-426

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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)