Nebulized therapy in pediatrics

Abstract

Inhalation therapy is a modern and preferable method of drug delivery which is currently used for treatment of majority of acute and chronic respiratory diseases in children and adults. Recently, inhalation devices have evolved significantly. Scientific researches are focused on interaction between drug molecules and aerosol-producing device. The efficacy of inhalation therapy is generally depends on the drug, its dose and technical parameters of the device. Inhalation devices that are able effectively produce drug aerosol have been used for treatment of most pediatric diseases. Advantages of this therapy are quick onset of the action, the possibility to reduce a drug dose due to higher drug concentration in the airways and to decrease the risk of adverse events, and independence of the liver metabolism. Nebulized therapy has been currently used for therapy of the majority of pediatric respiratory diseases. Drug formulation diversity and ability to combine > 2 drugs could enhance the treatment efficacy.