Respiratory outcomes of bronchopulmonary dysplasia in children, adolescents and adults
https://doi.org/10.18093/0869-0189-2017-27-1-87-96
Abstract
Prematurity and bronchopulmonary dysplasia (BPD), which is a complication of the neonatal respiratory distress-syndrome and respiratory therapy in neonates, are currently considered as possible risk factors of chronic obstructive pulmonary disease (COPD) in adults. Persisting reduction in the lung size in prematurely born children and pathological lesion typical for BPD can lead to ventilation disorders and clinical signs of chronic respiratory failure and / or bronchial obstruction in the children, adolescents and adults. Clinical, functional and morphological consequences of prematurity and BPD in preschool and school-aged children, adolescents and adults are discussed in this review considering the authors’ experience and the published data. The lung function abnormalities persist for lifetime. The lung tissue structural lesions, such as emphysema, fibrosis, the bronchial wall thickening, could be found on computed tomography. Therefore, patients with the history of BPD should be treated as risk group for early development of COPD.
About the Authors
E. V. Boytsova
Research Pulmonology Institute, Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Leading Researcher, Division of Therapeutic Pulmonology, Research Clinical Center
Russian Federation
Doctor of Medicine, Professor, Leading Researcher, Division of Therapeutic Pulmonology, Research Clinical Center
O. N. Titova
Research Pulmonology Institute, Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Director
Russian Federation
Doctor of Medicine, Director
D. Yu. Ovsyannikov
The Peoples' Friendship University of Russia
Russian Federation
Doctor of Medicine, Head of Department of Pediatrics
Russian Federation
Doctor of Medicine, Head of Department of Pediatrics
A. V. Bogdanova
Research Pulmonology Institute, Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Leading Researcher, Division of Therapeutic Pulmonology
Russian Federation
Doctor of Medicine, Professor, Leading Researcher, Division of Therapeutic Pulmonology
References
1. Baraldi E., Filippone M. Chronic lung disease after premature birth. N. Engl. J. Med. 2007; 357: 1946–1955. DOI: 10.1056/NEJMra067279.
2. Greenough A, Kotecha S. Bronchopulmonary dysplasia: current models and concepts. Eur. Respir. Mon. 2006; 37: 217–233.
3. Coalson J.J. Pathology of bronchopumonary dysplasia. Semin. Perinatol. 2006; 30 (4): 179–184. DOI: 10.1053/j.semperi.2006.05.004.
4. Ovsyannikov D.Yu. Bronchopulmonary dysplasia: natural course, outcomes and a control. Pediatriya. 2011; 90 (1): 141–150 (in Russian).
5. Bogdanova A.V., Boytsova E.V., Starevskaya S.V. et al. Clinical signs and course of bronchopulmonary dysplasia. Pul'monologiya. 2002; (1): 28–32 (in Russian).
6. May С., Kennedy C., Milner A.D. et al. Lung function abnormalities infants developing bronchopulmonary dysplasia. Arch. Dis. Child. 2011; 96: 1014–1019. DOI: 10.1136/adc.2011.212332.
7. Glowacka E., Lis G. Bronchopulmonary dysplasia – early and long-term pulmonary sequelae. Pneumonol. Alergol. Pol. 2008; 76 (6): 437–445.
8. Kwinta P., Lis G., Klimek M. et al. The prevalence and risk factors of allergic and respiratory symptoms in a regional cohort of extremely low birth weight children (<1000 g). Italian J. Pediatr. 2013; 39 (4): 1–11. DOI: 10.1186/1824-7288-39-4.
9. Broughton S., Thomas M.R., Marston L. et.al. Very prematureely born infants wheezing at follow-up:lung function and risk factors. Arch. Dis. Child. 2007; 92 (9): 776–780. DOI: 10.1136/adc.2006.112623.
10. Wong P.M., Lees A.N., French N. et al. Emphysema in yang adult survors of moderate-to-severe bronchopulmonary dysplasia. Eur. Respir. J. 2008; 32: 321–328. DOI: 10.1183/09031936.00127107.
11. Howling S.J., Northway W.H. Jr, Hansell D.M. et al. Pulmonary sequelae of bronchopulmonary dysplasia survivors: high-resolution CT findings. Am. J. Roentgenol. 2000; 174 (5): 1323–1326. DOI: 10.2214/ajr.174.5.1741323.
12. Guimaraes H., Rocha G., Pissarra S. et al. Respiratory outcomes and atopy in school-age children who were preterm at birth, with and without bronchopulmonary dysplasia. Clinics. 2011; 66 (3): 425–430. DOI: 10.1590/s1807-59322011000300011.
13. Lamarche-Vadel A., Blondel B., Truffer P. et al. Re-hospitalization in infants younger than 29 weeks gestation in the EPIPAGE cohort. Acta. Pediatr. 2004; 93 (10): 1340–1345.
14. Peґrez G., Navarro Merino M. Bronchopulmonary dysplasia and prematurity. Short-and long-term respiratory changes. Ann. Pediatr. 2010; 72 (79): 1–16. DOI: 10.1016/j.anpedi.2009.09.010.
15. McLeod A., Ross P., Mitchell S. et al. Respiratory health in a total very low birthweight cohort and their classroom controls. Arch. Dis. Child. 1996; 74 (3): 188–194. DOI: 10.1136/adc.74.3.188.
16. Northway W.H. Jr, Moss R.B., Carlisle K.B. et al. Late pulmonary sequelae of bronchopulmonary dysplasia. N. Engl. J. Med. 1990; 323: 1793–1799. DOI: 10.1056/NEJM199012273232603.
17. Been J.V., Lugtenberg M.J., Smets E. et al. Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis. PLoS Med. 2014; 11 (1): 1–17. DOI: 10.1371/journal.pmed.1001596.
18. Mai X.M, Gaddlin P.O., Nilsson L. et al. Asthma, lung function and allergy in 12-year-old children with very low birth weight: a prospective study. Pediatr. Allergy Immunol. 2003; 14 (3): 184–192.
19. Siltanen M., Wehkalampi K., Hovi P. et al. Preterm birth reduces the incidence of atopy in adulthood. J. Allergy Clin. Immunol. 2011; 127: 935–942. DOI: 10.1016/j.jaci.2010.12.1107.
20. Mieskonen S.T., Malmberg L.P., Kari M.A. et al. Exhaled nitric oxide at school age in prematurely born infants with neonatal chronic lung disease. Pediatr. Pulmonol. 2002; 33 (5): 347–355.
21. Roiha H.L., Kuehni C.E., Zanolari M. et al. Alterations of exhaled nitric oxide in pre-term infants with chronic lung disease. Eur. Respir. J. 2007; 29: 251–258. DOI: 10.1183/09031936.00016106.
22. Baraldi E., Bonetto G., Zacchello F. et al. Low exhaled nitric oxide in school-age children with bronchopulmonary dysplasia and airflow limitation. Am. J. Respir. Crit. Care Med. 2005; 171 (1): 68–72. DOI: 10.1164/rccm.200403-298OC.
23. Fawke J., Sooky L., Kirkby J. et al. Lung function and respiratory symptoms at 11 years in children born extremely preterm. Am. J. Respir. Crit. Care Med. 2010; 182 (2): 237–245. DOI: 10.1164/rccm.200912-1806OC.
24. Sue T.L., Stock Korhonen J.P., Laitinen J. et al. Respiratory outcome in school-aged, very-low-birth-weight children in the surfactant era. Acta. Pediatr. 2004; 93: 316–321.
25. Nixon P.A., Washburn L.K., Schechter M.S., O’Shea T.M. Follow-up study of a randomized controlled trial of postnatal dexamethasone therapy in very low birth weight infants: effects on pulmonary outcomes at 8–11 years of age. J. Pediatr. 2007; 150 (4): 345–350.
26. Landry J.S., Chan T., Lands L., Menzies D. Long-term impact of bronchopulmonary dysplasia on pulmonary function. Can. Respir. J. 2011; 18 (5): 265–270.
27. Konefał H., Czeszyńska M.B., Merritt T.A. School-age spirometry in survivors of chronic lung disease of prematurity in the surfactant era. Ginekol. Pol. 2013; 84 (4): 286–292.
28. Halvorsen T., Skadberg B.T., Eide G.E .et al. Pulmonary outcome in adolescents of extreme preterm birth: a regional cohort study. Acta. Paediatr. 2004; 93 (10): 1294–1300.
29. Doyle L.W., Cheung M.M., Ford G.W. et al. Birth weight <1501 g and respiratory health at age 14. Arch. Dis. Child. 2001; 84 (1): 40–44.
30. Doyle L.W. Respiratory function at age 8–9 years in extremely low birthweight/very preterm children in Victoria in 1991–1992. Pediatr. Pulmonol. 2006; 41 (6): 570–576. DOI: 10.1002/ppul.20412.
31. Doyle L.W., Faber B., Callanan C. et al. Bronchopulmonary dysplasia in very low birth weight subjects and lung function in late adolescence. Pediatrics. 2006; 118 (1): 108–113. DOI: 10.1542/peds.2005-2522.
32. Vrijlandt E.J., Gerritsen J., Boezen H.M. et al. Lung function and exercise capacity in young adults born prematurely. Am. J. Respir. Crit. Care Med. 2006; 173 (8): 890–896. DOI: 10.1164/rccm.200507-1140OC.
33. de Kleine M.J., Roos C.M., Voorn W.J. et al. Lung function 8–18 years after intermittent positive pressure ventilation for hyaline membrane disease. Thorax. 1990; 45 (12): 941–946.
34. Narang I., Rosenthal M., Cremonesini D. et al. Longitudinal evaluation of airway function 21 years after preterm birth. Am. J. Respir. Crit. Care Med. 2008; 178 (1): 74–80. DOI: 10.1164/rccm.200705-701OC.
35. Mieskonen S., Eronen M., Malmberg L.P. et al. Controlled trial of dexamethasone in neonatal chronic lung disease: an 8-year follow-up of cardiopulmonary function and growth. Acta Paediatr. 2003; 92 (8): 896–904.
36. Mitchel S.H., Teague W.G. Reduced gas transfer and during and exercise in shhool-age survivors of bronchopulmonary dyplasia. Am. J. Respir. Crit. Care Med. 1998; 157 (5, Pt 1): 1406–1412. DOI: 10.1164/ajrccm.157.5.9605025.
37. Parat S., Moriette G., Delaperche M.-F. et al. Long-term pulmonary functional outcome of bronchopulmonary dysplasia and birth. Pediatr. Pulmonol. 1995; 20 (5): 289–296.
38. Karnaushkina M.A., Strutynskaya A.D., Ovsyannikov D.Yu. Prematurity and the early childhood lower respiratory infection as risk factors of adulthood chronic obstructive lung disease. Sovremennye tekhnologii v meditsine. 2017; 9 (1): 129–134 (in Russian).
39. Ovsyannikov D.Yu., Kustova O.V., Zaytseva N.O., et al. Imaging of bronchopulmonary dysplasia. Voprosy diagnostiki v pediatrii. 2011; 3 (4): 36–45 (in Russian).
40. Giacoia G.P., Venkataraman P.S., West-Wilson K.I., Faulkner M.J. Follow-up of school-age children with bronchopulmonary dysplasia. J. Pediatr. 1997; 130 (3): 400–408.
41. Aquino S.L., Schechter M.S., Chiles C. et al. High – resolution inspiratory and expiratory CT in older children and adult with bronchopulmonary dysplasia. AJR Am. J. Roentgenol. 1999; 173: 963–967. DOI: 10.2214/ajr.173.4.10511158.
42. Howling S.J., Northway W.H. Jr, Hansell D.M. et al. Pulmonary sequelae of bronchopulmonary dysplasia survivors: high-resolution CT findings. AJR Am. J. Roentgenol. 2000; 174 (5): 1323–1326. DOI: 10.2214/ajr.174.5.1741323.
43. Aukland S.M., Halvorsen T., Fosse K.R. et al. High-resolution CT of the chest in children and young adults who were born prematurely: findings in a population-based study. AJR Am. J. Roentgenol. 2006; 187 (4): 1012–1018. DOI: 10.2214/AJR.05.0383.
44. Boytsova E.V., Zapevalova E.Yu., Kirbyat'eva M.A. et al. Bronchiolitis obliterans as an outcome of bronchopulmonary dysplasia. In: Purin' V.I., ed. A Regional Pediatric Hospital: Clinical and Management Problems. Saint-Petersburg; 2012: 123–129 (in Russian).
45. Karnaushkina M.A., Ovsyannikov D.Yu., Boytsova E.V., Malyavin A.G. Chronic obstructive pulmonary disease: a probable outcome of bronchopulmonary dysplasia. Doktor.Ru. 2014; 2 (90): 10–16 (in Russian).
46. Bader D., Ramos A.D., Lew C.D. et al. Childhood sequelae of infant lung disease: exercise and pulmonary function abnormalities after bronchopulmonary dysplasia. J. Pediatr. 1987; 110 (5): 693–699.
47. Samet J.M., Tager I.B., Speizer F.E. The relation between respiratory illness and chronic air-flow obstruction in adulthood. Am. Rev. Respir. Dis. 1983; 127 (4): 508–523. DOI: 10.1164/arrd.1983.127.4.508.
48. The Global Strategy for the Diagnosis, Management and Prevention of COPD, 2012. http://www.goldcopd.org/
49. Stocks J., Samatha S. Early life influences on the development of chronic obstructive pulmonary disease. Ther. Adv. Respir. Dis. 2013; 7 (3): 161–173. DOI: 10.1177/1753465813479428.
50. Hilgendorff A., O'Reilly M.A. Bronchopulmonary dysplasia early changes leading to long-term consequences. Front Med. 2015; 12 (2): 2–10. DOI: 10.3389/fmed.2015.00002.
51. Reyburn B., Martin R.J., Prakash Y.S., MacFarlane P.M. Mechanisms of injury to the preterm lung and airway: implications for long-term pulmonary outcome. Neonatology. 2012; 101 (4): 345–352. DOI: 10.1159/000337355.
52. Bourbon J.R., Boucherat O., Boczkowski J. et al. Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets. Trends Mol. Med. 2009; 15 (4): 169–179. DOI: 10.1016/j.molmed.2009.02.003.
53. Chuchalin A.G., ed. Chronic Obstructive Pulmonary Disease. A Practical Handbook. Moscow; 2004 (in Russian).
54. Speer C.P. Inflammation and bronchopulmonary dysplasia: A continuing story. Semin. Fetal. Neonatal. 2006; 11 (5): 354–362. DOI: 10.1016/j.siny.2006.03.004.
55. Cederqvist K., Sorsa T., Tervahartiala T., Maisi P. et al. Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress. Pediatrics. 2001; 108 (3): 686–692.
56. Davydova I.V., Yatsyk T.V., Bershova M.A., and Basargina M.A. Matrix metalloproteinases as markers of bronchopulmonary dysplasia. Pul'monologiya. 2009; (4): 80–84
57. Doyle L.W., Olinsky A., Faber B., Callanan C. Adverse effects of smoking on respiratory function in young adults born weighing less than 1000 grams. Pediatrics. 2003; 112 (3, Pt 1): 565–569.
Review
For citations:
Boytsova E.V., Titova O.N., Ovsyannikov D.Yu., Bogdanova A.V. Respiratory outcomes of bronchopulmonary dysplasia in children, adolescents and adults. PULMONOLOGIYA. 2017;27(1):87-96. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-1-87-96
Views:
4723
Email this article 