Early eradication of Pseudomonas aeruginosa infection in cystic fibrosis
https://doi.org/10.18093/0869-0189-2017-27-1-81-86
Abstract
Severe pulmonary disease in patients with cystic fibrosis (CF) is defined by the airway Pseudomonas aeruginosa infection. P.aeruginosa has still being the leading pathogen which causes progressive respiratory disease and poor prognosis in CF. Adequate and timely treatment of the initial Pseudomonas acquisition could prevent transformation to the chronic infection. This review was aimed at descripting the current antibacterial regimens for early eradication in cases of the initial and recurrent P.aeruginosa acquisition and at discussing factors affecting the treatment efficacy. The early eradication of P.aeruginosa is necessary and extremely important in CF patients. The aggressive pharmacological therapy together with early detection and subsequent microbiological control plays the leading role for the early eradication. The first-line therapy after the initial pathogen acquisition is inhaled tobramycin.
About the Authors
N. Yu. Kashirskaya
Federal Medical Genetic Academic Center, Russian Academy of Science
Russian Federation
Doctor of Medicine, Professor, Principal Researcher at Laboratory of Genetic Epidemiology
Russian Federation
Doctor of Medicine, Professor, Principal Researcher at Laboratory of Genetic Epidemiology
E. L. Amelina
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Candidate of Medicine, Head of Laboratory of Cystic Fibrosis
Russian Federation
Candidate of Medicine, Head of Laboratory of Cystic Fibrosis
S. A. Krasovskiy
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia;
D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Candidate of Medicine, Senior Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; pneumologist at the 2nd Pulmonology Department, D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department
Russian Federation
Candidate of Medicine, Senior Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; pneumologist at the 2nd Pulmonology Department, D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department
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Review
For citations:
Kashirskaya N.Yu., Amelina E.L., Krasovskiy S.A. Early eradication of Pseudomonas aeruginosa infection in cystic fibrosis. PULMONOLOGIYA. 2017;27(1):81-86. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-1-81-86
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