Particularities of nitric oxide cycle in respiratory disease
https://doi.org/10.18093/0869-0189-2016-26-6-753-759
Abstract
This review describes unique components of nitric oxide (NO) cycle in humans. The NO cycle involves NOsynthase, NOsynthase independent component and oxidationreduction reactions. Substrates for NO synthesis could be nitric oxides, nitrite and nitrate anions, organic nitrates, and food nitrates and nitrites. A role of human microbiota has been discussed. A role of important components of nitrite reductase and nitrate reductase systems in the NO cycle, activation and deactivation mechanisms were also described including enzymes, cofactors, homeostasis parameters, etc. These findings help to understand regulatory mechanisms of NO cycle that is important for targeted treatment.
About the Authors
S. K. Soodaeva
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
ul. Odinnadtsataya Parkovaya 32, build. 4, Moscow, 105077, Russia;
ul. Trubetskaya 8, build. 2, Moscow, 119991, Russia
Doctor of Medicine, Professor, Head of Laboratory of Clinical and Experimental Biophysics, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; Professor at Department of Human Pathology, I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia; tel.: (495) 4655264
I. A. Klimanov
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
ul. Odinnadtsataya Parkovaya 32, build. 4, Moscow, 105077, Russia
Candidate of Medicine, Senior Researcher at Laboratory of Clinical and Experimental Biophysics, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (495) 4655264
L. Yu. Nikitina
Khanty-Mansiysk State Medical Academy
Russian Federation
Russian Federation
ul. Mira 40, Khanty-Mansiysk, 628007, Russia
Doctor of Medicine, Head of Department of Therapy, Faculty of Postgraduate Physician Training, Khanty Mansiysk State Medical Academy; tel.: (908) 8828620, факс: (3467) 324588
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Review
For citations:
Soodaeva S.K., Klimanov I.A., Nikitina L.Yu. Particularities of nitric oxide cycle in respiratory disease. PULMONOLOGIYA. 2016;26(6):753-759. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-6-753-759
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