SPECIAL CONSIDERATION OF ANTIBACTERIAL THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
https://doi.org/10.18093/0869-0189-2016-26-5-618-622
Abstract
Current guidelines consider timely diagnosis, treatment and prevention of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as an important goal of the management of patients with COPD. Frequent AECOPD accelerate lung function declining and decrease quality of life. AECOPD are essentially associated with worsening of the mucociliary clearance and are caused unfrequently by respiratory infection. A case report is included in the article. A male with AECOPD was treated with inhalation therapy without systemic antibiotics. Thiamphenicol, glycinate acetylcysteinate (Fluimucil antibiotic IT) was used along with the standard therapy of AECOPD due to its antibacterial, antioxidant and mucolytic activity. Dyspnea, sputum expectoration, physical tolerance of the patient and rhonchi on auscultation improved in 3 days of treatment. The authors have concluded that administration of this drug allowed reduction drug load and decrease a risk of adverse events associated with systemic drug exposure.
About the Authors
I. V. Demko
V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia: 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Krasnoyarsk State Territorial Clinical Hospital: 3a, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
MD, Professor, Head of Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
Russian Federation
MD, Professor, Head of Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
E. A. Sobko
V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia: 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Krasnoyarsk State Territorial Clinical Hospital: 3a, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
MD, Associate Professor at Head of Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia; Head of Division of Pulmonology and Allergy, Krasnoyarsk State Territorial Clinical Hospital
Russian Federation
MD, Associate Professor at Head of Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia; Head of Division of Pulmonology and Allergy, Krasnoyarsk State Territorial Clinical Hospital
I. A. Solov'eva
V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia: 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Krasnoyarsk State Territorial Clinical Hospital: 3a, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
PhD, Assistant Lecturer, Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
Russian Federation
PhD, Assistant Lecturer, Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
O. P. Ishchenko
V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia: 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Krasnoyarsk State Territorial Clinical Hospital: 3a, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
PhD, Assistant Lecturer at Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia; allergist at Krasnoyarsk State Territorial Clinical Hospital
Russian Federation
PhD, Assistant Lecturer at Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia; allergist at Krasnoyarsk State Territorial Clinical Hospital
A. Yu. Kraposhina
V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia: 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Russian Federation
PhD, Assistant Lecturer at Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
Russian Federation
PhD, Assistant Lecturer at Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
N. V. Gordeeva
V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia: 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Krasnoyarsk State Territorial Clinical Hospital: 3a, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
PhD, Senior Researcher, Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
Russian Federation
PhD, Senior Researcher, Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia
S. V. Chubarova
V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia: 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Krasnoyarsk State Territorial Clinical Hospital: 3a, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
PhD, Assistant Lecturer at Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia; allergist at Krasnoyarsk State Territorial Clinical Hospital
Russian Federation
PhD, Assistant Lecturer at Department of Internal Medicine No.2 and Postgraduate Physician Training Course, V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, Healthcare Ministry of Russia; allergist at Krasnoyarsk State Territorial Clinical Hospital
M. G. Mamaeva
Krasnoyarsk State Territorial Clinical Hospital: 3a, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
PhD, pulmonologist at Krasnoyarsk State Territorial Clinical Hospital
Russian Federation
PhD, pulmonologist at Krasnoyarsk State Territorial Clinical Hospital
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Review
For citations:
Demko I.V., Sobko E.A., Solov'eva I.A., Ishchenko O.P., Kraposhina A.Yu., Gordeeva N.V., Chubarova S.V., Mamaeva M.G. SPECIAL CONSIDERATION OF ANTIBACTERIAL THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. PULMONOLOGIYA. 2016;26(5):618-622. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-5-618-622
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