A ROLE OF HYPERTONIC SALINE SOLUTION IN TREATMENT OF CYSTIC FIBROSIS
https://doi.org/10.18093/0869-0189-2016-26-5-584-590
Abstract
Outcomes and prognosis in cystic fibrosis (CF) are generally related to severity of respiratory system injury. That is why new therapeutic methods are in focus. Mucolytic agents play an important role along with antibacterial therapy and kinesiotherapy. Hypertonic saline solution (HSS) is one of the most important mucolytic agents though it should be referred to as sputum rehydratant. A systematic review of safety and clinical efficacy of inhaled HSS (alone or in combination with hyaluronic acid) has been done in this article. A long-term treatment with inhaled HSS in combination with dornase alfa as a basic therapy of CF in various age groups of patients has been also discussed.
About the Authors
N. Yu. Kashirskaya
Federal Medical Genetic Academic Center, Russian Academy of Science: 1, Moskvorech'e str., Moscow, 1115478, Russia
Russian Federation
MD, Professor, Principal Researcher at Laboratory of Genetic Epidemiology
Russian Federation
MD, Professor, Principal Researcher at Laboratory of Genetic Epidemiology
V. D. Sherman
Federal Medical Genetic Academic Center, Russian Academy of Science: 1, Moskvorech'e str., Moscow, 1115478, Russia
Russian Federation
PhD, Senior Researcher at Research and Clinical Division of Cystic Fibrosis
Russian Federation
PhD, Senior Researcher at Research and Clinical Division of Cystic Fibrosis
N. I. Kapranov
Federal Medical Genetic Academic Center, Russian Academy of Science: 1, Moskvorech'e str., Moscow, 1115478, Russia
Russian Federation
MD, Professor, Principal Researcher at Research and Clinical Division of Cystic Fibrosis
Russian Federation
MD, Professor, Principal Researcher at Research and Clinical Division of Cystic Fibrosis
E. I. Kondrat'eva
Federal Medical Genetic Academic Center, Russian Academy of Science: 1, Moskvorech'e str., Moscow, 1115478, Russia
Russian Federation
MD, Professor, Principal Researcher at Research and Clinical Division of Cystic Fibrosis
Russian Federation
MD, Professor, Principal Researcher at Research and Clinical Division of Cystic Fibrosis
S. A. Krasovskiy
Federal Medical Genetic Academic Center, Russian Academy of Science: 1, Moskvorech'e str., Moscow, 1115478, Russia
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
3D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department: 32, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
PhD, Senior Researcher at Research and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center, Russian Academy of Science; Senior Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; pneumologist at the 2#nd Pulmonology Department of D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department
Russian Federation
PhD, Senior Researcher at Research and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center, Russian Academy of Science; Senior Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; pneumologist at the 2#nd Pulmonology Department of D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department
E. L. Amelina
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
PhD, Head of Laboratory of Cystic Fibrosis
Russian Federation
PhD, Head of Laboratory of Cystic Fibrosis
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For citations:
Kashirskaya N.Yu., Sherman V.D., Kapranov N.I., Kondrat'eva E.I., Krasovskiy S.A., Amelina E.L. A ROLE OF HYPERTONIC SALINE SOLUTION IN TREATMENT OF CYSTIC FIBROSIS. PULMONOLOGIYA. 2016;26(5):584-590. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-5-584-590
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