Efficacy of high frequency chest wall oscillation method in acute exacerbation of chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2016-26-4-466-472
Abstract
This study was aimed at investigation of clinical efficacy and safety of high frequency chest wall oscillation (HFCWO) method in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods. This was a prospective randomized controlled comparative study. Patients hospitalized for AECOPD (GOLD III or IV stage; mean FEV 1, 37% pred.) were included. In first two days of admission, all patients were randomized to HFCWO treatment (VestÒ Airway Clearance System; 15–25 min b.i.d.; oscillation frequency, 10–15 Hz; pressure, 4–6 cm H2O) or standard therapy (the control group). Results. Fifty patients completed the study: 25 patients in HFCWO group and 25 patients in the standard therapy group. Therapy with HFCWO was associated with increasing sputum volume to the 3rd and the 7th days of the study (р < 0.001) and more significant reduction in symptom intensity compared to the controls (р = 0.006). Symptom severity measured with the BCSS score decreased by 3.4 and 1.5, respectively (р = 0,006). Therapy with HFCWO was also associated with more significant improvement in oxygenation parameters and reduction in C-reactive protein (CRP) level (р = 0,001 for both). Conclusion. Therefore, treatment with HFCWO was associated to improved sputum clearance, significant improvement in clinical symptoms, earlier oxygenation improvement and CRP reduction.
About the Authors
S. N. Avdeev
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Clinical Division, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel. / fax: (495) 465-52-64;
N. A. Guseva
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
PhD student, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel. / fax: (495) 465-52-64;
G. S. Nuralieva
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
PhD, Senior Researcher at Laboratory of Intensive Care and Respiratory Failure, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel. / fax: (495) 465-74-15;
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Review
For citations:
Avdeev S.N., Guseva N.A., Nuralieva G.S. Efficacy of high frequency chest wall oscillation method in acute exacerbation of chronic obstructive pulmonary disease. PULMONOLOGIYA. 2016;26(4):466-472. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-4-466-472
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