2016 Influenza epidemics: clinical and epidemiological features and current abilities for effective treatment (according to data from the Clinical Infectious Diseases Hospital No. 1, Moscow)

L. V. Kolobukhina; E. I. Burtseva; I. S. Kruzhkova; L. N. Merkulova; R. V. Vartanyan; L. B. Kisteneva; E. S. Kirillova; S. V. Trushakova; A. G. Rosatkevich; K. G. Krasnoslobodtsev; E. A. Mukasheva; P. V. Boytsov; E. I. Kelli; O. E. Ambrosi; T. V. Arseneva; M. V. Bazarova; A. V. Devyatkin; O. A. Sutochnikova

doi:10.18093/0869-0189-2016-26-4-444-452

2016 Influenza epidemics: clinical and epidemiological features and current abilities for effective treatment (according to data from the Clinical Infectious Diseases Hospital No. 1, Moscow)

L. V. Kolobukhina, E. I. Burtseva, I. S. Kruzhkova, L. N. Merkulova, R. V. Vartanyan, L. B. Kisteneva, E. S. Kirillova, S. V. Trushakova, A. G. Rosatkevich, K. G. Krasnoslobodtsev, E. A. Mukasheva, P. V. Boytsov, E. I. Kelli, O. E. Ambrosi, T. V. Arseneva, M. V. Bazarova, A. V. Devyatkin, O. A. Sutochnikova

https://doi.org/10.18093/0869-0189-2016-26-4-444-452

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Abstract

The aim of this study was to monitor in-hospital influenza virus infection during 2015 – 2016 epidemic flu season. Methods. Influenza virus was searched in patients hospitalized to a clinical infectious diseases hospital with acute respiratory viral infection during 2015 – 2016 influenza seasonal growth period using real-time RT-PCR method. Influenza virus was isolated from nasal swabs and autopsy material using canine kidney cell line. Other laboratory methods used included complete blood count, blood chemistry, blood gas analysis, urinalysis, and chest X-ray examination. Results. We examined 1,491 patients (375 adults, 546 children, 570 pregnant women with early gestational age). The proportion of hospitalized patients with confirmed A / H1N1pdm09 influenza in January – February, 2016, was 91.3%. A / H3N2 influenza virus was diagnosed in 5.7%, influenza B virus was isolated in 1.2% of patients. Totally, influenza virus was detected in 35.2% of samples, of which 30.1% of samples were obtained from adults, 33.7% of samples were obtained from children, and 39.8% of samples were obtained from pregnant women. The prevalent patient’s age was 15 to 60 years (76.1%) in adults and 3 to 6 years in children. Moderate course of influenza with a high rate of hospital admission was seen more often and was similar to that of 2009 – 2010 epidemic season. Proportion of patients with flu complicated by pneumonia was higher than that in 2014 – 2015 epidemic season. Bilateral lung injury was diagnosed in 48.4% of patients. High mortality in ICU (46.4%) was due to delayed start of antiviral treatment and late admission to a hospital. Conclusion. In 2015 – 2016 epidemic flu season, higher morbidity, complications and poor outcomes were related to predominant infection of A – H1N1pdm09 influenza virus. Risk factors of complications and death were delayed care seeking, lack of modern antiviral medications and comorbidity.

Keywords

2015 – 2016 epidemic flu season, А / H1N1pdm09 influenza virus, clinical signs, etiotropic therapy, Ingavirin

About the Authors

L. V. Kolobukhina

D.I.Ivanovskiy Virology Institute, Federal Research Center of Epidemiology and Microbiology, Honorary Academician N.F.Gamaleya Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia: 16, Gamalei str., Moscow, 123098, Russia;
Russian Federation

MD, Head of Laboratory of Respiratory Viral Infections and Drug Testing, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (495) 490-14-15;

E. I. Burtseva

MD, Head of Laboratory of Influenza Etiology and Epidemiology, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (499) 190-30-46;

I. S. Kruzhkova

Junior Researcher at Laboratory of Respiratory Viral Infections and Drug Testing, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (495) 490-14-15;

L. N. Merkulova

PhD, Chief Scientist at Laboratory of Respiratory Viral Infections and Drug Testing, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (495) 490-14-15;

R. V. Vartanyan

L. B. Kisteneva

MD, Head of Laboratory of Epidemiology, Prevention and Diagnosis of Viral Hepatitis and Clinical Division, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (495) 490-14-15;

E. S. Kirillova

PhD, Chief Scientist at Laboratory of Influenza Etiology and Epidemiology, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (499) 190-30-46;

S. V. Trushakova

PhD in Biology, Researcher at Laboratory of Influenza Etiology and Epidemiology, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (499) 190-30-46;

A. G. Rosatkevich

Junior Researcher at D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (495) 490-14-15;

K. G. Krasnoslobodtsev

Researcher at Laboratory of Influenza Etiology and Epidemiology, D.I.Ivanovskiy Virology Institute, Honorary Academician N.F.GamaleyaFederal Research Center of Epidemiology and Microbiology, Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (499) 190-30-46;

E. A. Mukasheva

P. V. Boytsov

State Clinical Infectious Diseases Hospital No. 1, Moscow Healthcare Department: 63, Volokolamskoe av., Moscow, 125367, Russia;
Russian Federation
Head of Anesthesiology and Emergency Department, State Clinical Infectious Diseases Hospital No.1, Moscow Healthcare Department; tel.: (499) 193-83-55;

E. I. Kelli

State Clinical Infectious Diseases Hospital No. 1, Moscow Healthcare Department: 63, Volokolamskoe av., Moscow, 125367, Russia;
Russian Federation
Head of Department of Pathology, State Clinical Infectious Diseases Hospital No.1, Moscow Healthcare Department; tel.: (495) 490-14-16;

O. E. Ambrosi

State Clinical Infectious Diseases Hospital No. 1, Moscow Healthcare Department: 63, Volokolamskoe av., Moscow, 125367, Russia;
Russian Federation
radiologist at State Clinical Infectious Diseases Hospital No.1, Moscow Healthcare Department; tel.: (499) 193-63-00;

T. V. Arseneva

State Clinical Infectious Diseases Hospital No. 1, Moscow Healthcare Department: 63, Volokolamskoe av., Moscow, 125367, Russia;
Russian Federation
Head of Radiology Department, State Clinical Infectious Diseases Hospital No.1, Moscow Healthcare Department; tel.: (499) 193-63-00;

M. V. Bazarova

State Clinical Infectious Diseases Hospital No. 1, Moscow Healthcare Department: 63, Volokolamskoe av., Moscow, 125367, Russia;
Russian Federation
PhD, Deputy Chief Officer for Disease Control and Prevention at State Clinical Infectious Diseases Hospital No.1, Moscow Healthcare Department; tel.: (495) 490-14-14;

A. V. Devyatkin

State Clinical Infectious Diseases Hospital No. 1, Moscow Healthcare Department: 63, Volokolamskoe av., Moscow, 125367, Russia;
Russian Federation
MD, Hospital Chief Executive Officer at State Clinical Infectious Diseases Hospital No.1, Moscow Healthcare Department; tel.: (495) 490-14-14;

O. A. Sutochnikova

Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation

PhD, Senior Researcher at Laboratory of Intensive Care and Respiratory Failure, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; 32, build. 4, 11^th Parkovaya str., Moscow, 105077, Russia; tel.: (495) 465-52-64;

References

1. Karpova L.S., Sominina A.A., Burtseva E.I. et al. A comparison between influenza epidemics caused by pandemic influenza A (H1N1) virus in 2009 – 2013 in Russia. Voprosy virusologii. 2015; 60 (3): 19–25 (in Russian).

2. L'vov D.K., Burtseva E.I., Kolobukhina L.V., et al. Characterization of influenza epidemic season 2014 / 2015 in different regions of Russia. Infektsionnye bolezni. 2015; 4: 59–67 (in Russian).

3. http://www.who.int/flunet

4. www.influenza.spb.ru/system/epidemiological_situation

5. L'vov D.K., Burtseva E.I., Kolobukhina L.V., et al. Virological, epidemiological, clinical and molecular features of 2015 – 2016 influenza epidemics: prevalence of A (H1N1) pdm09 virus in Russia and in countries of the Northern Hemisphere. Voprosy virusologii. 2016; 61 (4): 159–166 (in Russian).

6. Federal Service for Supervision of Consumer Rights Protection and Human Welfare. About improvement in epidemiological surveillance and control of influenza and other acute respiratory viral infections. The order No.373, Mar 31, 2005 (in Russian).

7. About improvement in monitoring of pathogens caused infectious and parasitic diseases. The order No.88, Mar 17, 2008 (in Russian).

8. Sominina A.A., Burtseva E.I., Lobova T.G., et al. Influenza virus culturing and identification in cell cultures and chicken embryons. Methodological guidelines (approved by Federal Service for Supervision of Consumer Rights Protection and Human Welfare. Moscow; 2006 (in Russian).

9. L'vov D.K., Burtseva E.I., Prilipov A.G., et al. A potential relationship between fatal pneumonia and mutations in the receptor binding site of pandemic A / H1N1 swl influenza virus hemagglutinin HA1 subunit. Voprosy virusologii. 2010; 55 (4): 4–9 (in Russian).

10. Russian Respiratory Society. National Guidelines on Diagnosis and Treatment of Severe Influenza. 2013. Available at: http://www.pulmonology.ru (in Russian).

11. Avdeev SN. Pneumonia and acute respiratory distress-syndrome caused by A / H1N1 influenza virus. Pul'monologiya. 2010. Suppl.: 32–46 (in Russian).

12. Chuchalin A.G., Chernyaev A.L., Zayrat'yants O.V., et al. Lung pathology in A / H1N1 influenza: autopsy data. Pul'monologiya. 2010; 1: 5–11 (in Russian).

13. Nicholson K.G., Aoki F.Y., Osterhaus A.D. et al. Efficacy and safety of oseltamivir in treating of acute influenza: a randomized controlled trial. Neuraminidase inhibitor Flu Treatment Investigator Group. Lancet. 2000; 355 (9218): 1845–1850.

14. Kolobukhina L.V., Merkulova L.N., Burtseva E.I., et al. Oseltamivir (Tamiflu®): an opportunity of effective therapy of influenza. Russkiy meditsinskiy zhurnal. 2008; 16 (2): 69–73 (in Russian).

15. Methodological Guidelines on Diagnosis and Treatment of Influenza. Available at: https://www.rosminzdrav.ru (in Russian).

16. Kolobukhina L.V., Shchelkanov M.Yu., Proshina E.S., et al. Clinical and pathogenic features and improvement in antiviral treatment of pandemic A (H1N1) pdm09 influenza virus. Voprosy virusologii. 2012; Suppl. 1: 189–198 (in Russian).

17. Ashakher T., Krokhin A., Kuznetsova I., et al. Effects of Ingavirin® (imidazolyl-ethanamide pentandioic acid) on cell interferon production in viral infection. Epidemiologiya i infektsionnye bolezni. 2016; 21 (4): 196–205 (in Russian).

18. Sokolova T.M., Shuvalov A.N., Poloskov V.V., et al. Signal transduction gene stimulation by Ridostin, Cycloferon and Ingavirin drugs. Tsitokiny i vospalenie. 2015; 14 (2): 26–34 (in Russian).

19. Zarubaev V.V., Garshinina A.V., Kalinina N.A., et al. Protective activity of Ingavirin in experimental fatal pneumonia caused by pandemic A (H1N1)v influenza virus in white mice. Antibiotiki i khimioterapiya. 2010; 55 (5–6): 24–31 (in Russian).

20. Zarubaev V.V., Belyaevskaya S.V., Sirotkin A.K., et al. Effects of Ingavirin® on ultrastructure and infectivity of influenza virus in vitro and in vivo. Voprosy virusologii. 2011; 56 (5): 21–25 (in Russian).

21. Chuchalin A.G., Kolobukhina L.V. A (H1N1) swl influenza: clinical aspects, diagnostic algorithm and therapeutic strategy. Investigation of Virus Evolution Within the Framework on Biosafety and Social Significant Infections. Proceedings of the Scientific Conference. Feb 24; 2011. 2011: 17–30 (in Russian).

22. Chuchalin A.G. Influenza: lesions from the pandemia (clinical aspects). Pul'monologiya. 2010; Suppl.: 3–8 (in Russian).

23. http://eapatis.com/ruSearch/ms.exeData/EAPO/eapo2014/WIPO/201490750.pdf. (No. WO 2013/055258 A 2; PCT/RU2012/000821).

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For citations:

Kolobukhina L.V., Burtseva E.I., Kruzhkova I.S., Merkulova L.N., Vartanyan R.V., Kisteneva L.B., Kirillova E.S., Trushakova S.V., Rosatkevich A.G., Krasnoslobodtsev K.G., Mukasheva E.A., Boytsov P.V., Kelli E.I., Ambrosi O.E., Arseneva T.V., Bazarova M.V., Devyatkin A.V., Sutochnikova O.A. 2016 Influenza epidemics: clinical and epidemiological features and current abilities for effective treatment (according to data from the Clinical Infectious Diseases Hospital No. 1, Moscow). PULMONOLOGIYA. 2016;26(4):444-452. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-4-444-452

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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)

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PULMONOLOGIYA

2016 Influenza epidemics: clinical and epidemiological features and current abilities for effective treatment (according to data from the Clinical Infectious Diseases Hospital No. 1, Moscow)

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Abstract

Keywords

About the Authors

References

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