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Lower respiratory infection in patients with cystic fibrosis in Russian Federation according to the National Register, 2014

https://doi.org/10.18093/0869-0189-2016-26-4-421-435

Abstract

The aim of this study was to characterize chronic respiratory infection in cystic fibrosis (CF) patients in Russia according to the National Russian CF Register. Methods. The National Russian CF Register included 2,131 patients from 74 Russian regions (2,092 alive patients and 39 died patients) in 2014 (the median age, 10.2 (15.2) years; 29.2% were adults ≥ 18 лет). Microbiological findings of CF patients (chronic infection caused by Staphylococcus aureus, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Burkholderia cepacia соmplex, non-tuberculous mycobacteria (NTM), non-Pseudomonas Gram negative pathogens including Achromobacter spp., and frequency of intermittent P. aeruginosa infection) have been analyzed in this article. Results. The tested pathogens were not found in 18.0% of patients. The prevalence of pathogens in descending order was as follows: S. aureus, 54,5%; P. aeruginosa, (chronic infection), 32,1%; P. aeruginosa (intermittent infection), 14,1%; B. cepacia complex, 7,3%; Achromobacter spp., 3,5%; Stenotrophomonas maltophilia, 3,3%; NTM, 0,8%. Other non-Pseudomonas Gram negative pathogens including Achromobacter spp., Escherichia coli, Acinetobacter spp., Klebsiella spp., Citrobacter spp. caused chronic airway infection in 11.8% of patients. Children were infected more frequently by S. aureus and adult patients infected were frequently by P. aeruginosa, В.сepacia complex, Achromobacter spp., and NTM. No geographic prevalence of pathogen distribution was found. Russian CF patients were more often infected by S. aureus and B. cepacia complex compared to European CF patients. P. aeruginosa was yielded with equal rate in Russia and in Europe. S. maltophilia and NTM were found less frequently in Russia compared to Europe. Conclusion. According to the National Russian CF Register, the airways of 18.0% of CF patients in Russia are not colonized by respiratory pathogens. As the patient's age increases, the rate of Gram negative respiratory infection is growing. The most harmful infections are thought to be B. cepacia complex and Achromobacter spp.

About the Authors

S. A. Krasovskiy
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

Krasovskiy Stanislav Aleksandrovich, PhD, Senior Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (495) 965-23-24;


E. L. Amelina
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

PhD, Head of Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (499) 780-08-06;


E. I. Kondrat'eva
Federal Medical Genetic Academic Center, Russian Academy of Medical Science: 1, Moskvorech'e str., Moscow, 1115478, Russia;
Russian Federation

MD, Professor, Principal Researcher at Scientific and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center, Russian Academy of Medical Science; tel.: (499) 137-01-97;


I. A. Shaginyan
N.F.Gamaleya Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia: 18, Gamalei str., Moscow, 123098, Russia;
Russian Federation

MD, Head of Laboratory of Molecular Epidemiology of Hospital Infections, N.F. Gamaleya  Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (906) 770-78-90;


M. Yu. Chernukha
N.F.Gamaleya Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia: 18, Gamalei str., Moscow, 123098, Russia
Russian Federation

MD, Chief Scientist at Laboratory of Molecular Epidemiology of Hospital Infections, N.F. Gamaleya  Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: (499)193-55-94;


A. V. Chernyak
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

PhD, Head of Laboratory of Functional and Ultra-sound Investigations; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (495) 465-53-84;


N. Yu. Kashirskaya
Federal Medical Genetic Academic Center, Russian Academy of Medical Science: 1, Moskvorech'e str., Moscow, 1115478, Russia;
Russian Federation

MD, Professor, Principal Researcher at Laboratory of Genetic Epidemiology, Federal Medical Genetic Academic Center, Russian Academy of Medical Science; tel.: (499) 320-60-90;


L. R. Avetisyan
N.F.Gamaleya Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia: 18, Gamalei str., Moscow, 123098, Russia;
Russian Federation

PhD, Senior Researcher at Laboratory of Molecular Epidemiology of Hospital Infections, N.F. Gamaleya  Federal Research Center for Epidemiology and Microbiology, Healthcare Ministry of Russia; tel.: 903) 123-16-11;


S. V. Polikarpova
O.V.Filatov State Clinical Hospital No.15, Moscow Healthcare Department: 23, Veshnyakovskaya str., Moscow, 111539, Russia;
Russian Federation

PhD, Head of Bacteriological Laboratory, O.V.Filatov State Clinical Hospital No. 15, Moscow Healthcare Department; tel.: (495) 375-12-24;


N. V. Pivkina
O.V.Filatov State Clinical Hospital No.15, Moscow Healthcare Department: 23, Veshnyakovskaya str., Moscow, 111539, Russia;
Russian Federation

physician at Bacteriological Laboratory, O.V.Filatov State Clinical Hospital No. 15, Moscow Healthcare Department; tel.: (495) 375-12-24;


A. Yu. Voronkova
Federal Medical Genetic Academic Center, Russian Academy of Medical Science: 1, Moskvorech'e str., Moscow, 1115478, Russia;
Russian Federation

PhD, Senior Researcher at Scientific and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center, Russian Academy of Medical Science; tel.: (499) 137-01-97;


M. V. Usacheva
Federal Medical Genetic Academic Center, Russian Academy of Medical Science: 1, Moskvorech'e str., Moscow, 1115478, Russia;
Russian Federation

Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (495) 965-23-24;


Yu. E. Kalinina
Tula State Regional Pediatric Clinical Hospital: 39, Bondarenko str., Tula, 300010, Russia;
Russian Federation

Head of Pulmonology Department of Tula State Regional Pediatric Clinical Hospital; tel.: (4872) 48-01-30;


N. A. Kanukova
Stavropol' Territorial Clinical Referral Diagnostic Center: 304, Lenina str., Stavropol', 355017, Russia;
Russian Federation

pulmonologist at Stavropol' Territorial Clinical Referral Diagnostic Center; Chief Pulmonologist of Healthcare Ministry of Stavropol' kray; tel.: (8652) 95-19-51;


L. S. Kozyreva
G.G.Kuvatov Republic State Clinical Hospital: 132, Dostoevskogo str., Ufa, 405005, the Republic of Bashkortostan;
Russian Federation

PhD, physician at Pulmonology Department of G.G.Kuvatov Republic State Clinical Hospital; tel.: (347) 272-23-85;


Yu. A. Kondakova
Novosibirsk City State Pediatric Emergency Clinical Hospital: 3, Krasnyy prospekt, Novosibirsk, 630007, Russia;
Russian Federation

pediatrician at Novosibirsk City State Pediatric Emergency Clinical Hospital; tel.: (3832) 23-16-94;


L. E. Konovalova
Leningrad Regional State Pediatric Clinical Hospital: 6, Komsomola str., Saint-Petersburg, 195009, Russia;
Russian Federation

Head of Department of Pulmonology, Leningrad Regional State Pediatric Clinical Hospital; tel.: (812) 542-53-62;


T. Yu. Korneeva
Omsk Regional Pediatric Clinical Hospital: 77, Kuybysheva str., Omsk, 644001, Russia;
Russian Federation

physician at Pulmonology Department of Omsk Regional Pediatric Clinical Hospital, tel.: (3812) 37-30-68;


Yu. V. Gorinova
Federal Academic Centre of Children's Health, Healthcare Ministry of Russia: 2, build.1, Lomonosovskiy av., Moscow, 119991, Russia;
Russian Federation

PhD, Senior Researcher at Division of Pulmonology and Allergy, Federal Academic Centre of Children's Health, Healthcare Ministry of Russia; tel.: (499) 134-93-31;


A. E. Lavrova
Privolzhskiy Federal Medical Research Center, Healthcare Ministry of Russia: 18, Verkhne-Volzhskaya embankment, Nizhniy Novgorod, 603155, Russia;
Russian Federation

MD, Principal Researcher at Clinics of Gastroenterology and Metabolic Disorders; Head of Department of Gastroenterology and Metabolic Disorders, Privolzhskiy Federal Medical Research Center, Healthcare Ministry of Russia; tel.: (831) 436-03-84;


L. N. Ledeneva
Stavropol’ State Medical University, Healthcare Ministry of Russia: 310, Mira str., Stavropol', 355029, Russia;
Russian Federation

PhD, Associate Professor at Department of Hospital Pediatrics, Stavropol’ State Medical University, Healthcare Ministry of Russia; tel.: (962) 450-08-94;


V. S. Ledneva
N.N.Burdenko Voronezh State Medical University, Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia;
Russian Federation
MD, Associate Professor at Department of Propaedeutics of Pediatric Diseases, N.N.Burdenko Voronezh State Medical University, Healthcare Ministry of Russia; tel.: (4732) 65-65-62;


D. E. Lyagusha
Kuban State Medical University, Healthcare Ministry of Russia: 4, Sedina str., Krasnodar, 350063, Russia;
Russian Federation

Assistant Lecturer at Department of Hospital Pediatrics, Kuban State Medical University, Healthcare Ministry of Russia; tel.: (861) 268-54-18;


O. I. Golubtsova
Republic Pediatric Clinical Hospital, Chuvash Healthcare Ministry: 27, Gladkova str., Cheboksary, 428020, the Republic of Chuvas;
Russian Federation

PhD, Head of Division of Pulmonology and Allergy, Republic Pediatric Clinical Hospital; tel.: (8352) 55-01-26;


N. B. Merzlova
E.A.Vagner Perm' State Medical Academy Healthcare Ministry of Russia: 22, Baumana str., Perm', 614066, Russia;
Russian Federation

MD, Professor, Head of Department of Hospital Pediatrics, E.A.Vagner Perm State Medical Academy Healthcare Ministry of Russia; tel.: (342) 221-86-15;


V. V. Mukhacheva
Federal Research Institute of Medical Genetics, Siberian Department of Russian Academy of Medical Science: 3, Moskovskiy tract, Tomsk, 634050, Russia;
Russian Federation

pediatrician at Federal Research Institute of Medical Genetics, Siberian Department of Russian Academy of Medical Science; tel.: (913)103-09-51;


V. S. Nikonova
Federal Medical Genetic Academic Center, Russian Academy of Medical Science: 1, Moskvorech'e str., Moscow, 1115478, Russia;
Russian Federation

PhD, Senior Researcher at Scientific and Clinical Division of Cystic Fibrosis, Federal Medical and Genetic Academic Center, Russian Academy of Medical Science; tel.: (499) 137-01-97;


A. F. Neretina
N.N.Burdenko Voronezh State Medical University, Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia;
Russian Federation
MD, Professor at Department of Propaedeutics of Pediatric Diseases, N.N.Burdenko Voronezh State Medical University, Healthcare Ministry of Russia; tel.: (4732) 20-22-33;


O. B. Novikova
Smolensk State Medical Academy, Healthcare Ministry of Russia: 30v, Marshala Koneva str., Smolensk, 214019, Russia;
Russian Federation

PhD, Associate Professor at Department of Hospital Pediatrics and Neonatology, Faculty of Postgraduate Physician Training, Smolensk State Medical Academy, Healthcare Ministry of Russia; tel.: (4812) 55-54-94;


E. V. Osipova
The First Republic Clinical Hospital, Healthcare Ministry of the Udmurtia Repiblic: 57, Votkinskoe av., Izhevsk, 426039, the Udmurtia Repiblic;
Russian Federation

PhD, Head of Medical Genetic Counselling, The First Republic Clinical Hospital, Healthcare Ministry of the Udmurtia Repiblic; tel.: (3412) 46-87-71;


O. V. Usacheva
Yaroslavl' Pediatric State Clinical Hospital No.1: 12/76, Lenina av., Yaroslavl', 150003, Russia;
Russian Federation

pulmonologist at Yaroslavl' Pediatric State Clinical Hospital No.1; tel.: (910) 821-85-44;


P. I. Pavlov
Chuvash Republic Clinical Hospital, Chuvash Healthcare Ministry: 9, Moskovskiy av., Cheboksary, 428018, the Republic of Chuvas;
Russian Federation
Head of Department of Pulmonology, Chuvash Republic Clinical Hospital, Chuvash Healthcare Ministry; tel.: (8352) 58-29-89;


Yu. S. Pinegina
Novosibirsk State Regional Clinical Hospital: 130, Nemirovicha-Danchenko str., Novosibirsk, 630087, Russia;
Russian Federation

PhD, Head of Department of Pediatric Pulmonology, Novosibirsk State Regional Clinical Hospital; tel.: (383) 315-99-78;


A. I. Petrova
Chita State Medical Academy, Healthcare Ministry of Russia: 39a, Gor'kogo str., Chita, 672090, Russia;
Russian Federation

Resident Physician at Department of Pediatrics, Chita State Medical Academy, Healthcare Ministry of Russia; tel.: (3022) 23-63-70;


I. V. Polyakova
Stavropol’ State Medical University, Healthcare Ministry of Russia: 310, Mira str., Stavropol', 355029, Russia;
Russian Federation

PhD student at Department of Hospital Pediatrics, Stavropol’ State Medical University, Healthcare Ministry of Russia; tel.: (918) 864-76-44;


D. F. Ibragimova
N.V.Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department: 3, Bol. Sukharevskaya sq., Moscow, 129090, Russia;
Russian Federation

Researcher at Department of Emergent Thoracic and Abdominal Surgery, .V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; tel.: (926) 891-53-38;


T. A. Ponomareva
Stavropol’ State Medical University, Healthcare Ministry of Russia: 310, Mira str., Stavropol', 355029, Russia;
Russian Federation

Assistant Lecturer at Department of Hospital Pediatrics, Stavropol’ State Medical University, Healthcare Ministry of Russia; tel.: (918) 753-33-41;


T. A. Protasova
Kemerovo State Regional Clinical Hospital: 22, Oktyabr'skiy av., Kemerovo, 650066, Russia;
Russian Federation

Head of Department of Acute Respiratory Infections, Kemerovo State Regional Clinical Hospital; tel.: (3842) 39-64-21;


O. G. Pyaterkina
State Republic Pediatric Clinical Hospital, Healthcare Ministry of the Republic of Tatarstan: 140, Orenburgskiy tract, Kazan', 420138, the Republic of Tatarstan;
Russian Federation

Head of Outpatient Counseling No.1, State Republic Pediatric Clinical Hospital, Healthcare Ministry of the Republic of Tatarstan; tel.: (905) 317-33-06;


D. F. Sergienko
Astrakhan' State Medical Academy, Healthcare Ministry of Russia: 121, Bakinskaya str., Astrakhan', 414000, Russia
Russian Federation

MD, Professor at General Pediatrics, Astrakhan' State Medical Academy, Healthcare Ministry of Russia; tel.: (8512) 52-41-43;


N. I. Kapranov
Federal Medical Genetic Academic Center, Russian Academy of Medical Science: 1, Moskvorech'e str., Moscow, 1115478, Russia;
Russian Federation

MD, Professor, Principal Researcher at Clinical and Research Division of Cystic Fibrosis, Federal Medical Genetic Academic Center, Russian Academy of Medical Science; tel.: (499)137-01-97;


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Review

For citations:

Krasovskiy S.A., Amelina E.L., Kondrat'eva E.I., Shaginyan I.A., Chernukha M.Yu., Chernyak A.V., Kashirskaya N.Yu., Avetisyan L.R., Polikarpova S.V., Pivkina N.V., Voronkova A.Yu., Usacheva M.V., Kalinina Yu.E., Kanukova N.A., Kozyreva L.S., Kondakova Yu.A., Konovalova L.E., Korneeva T.Yu., Gorinova Yu.V., Lavrova A.E., Ledeneva L.N., Ledneva V.S., Lyagusha D.E., Golubtsova O.I., Merzlova N.B., Mukhacheva V.V., Nikonova V.S., Neretina A.F., Novikova O.B., Osipova E.V., Usacheva O.V., Pavlov P.I., Pinegina Yu.S., Petrova A.I., Polyakova I.V., Ibragimova D.F., Ponomareva T.A., Protasova T.A., Pyaterkina O.G., Sergienko D.F., Kapranov N.I. Lower respiratory infection in patients with cystic fibrosis in Russian Federation according to the National Register, 2014. PULMONOLOGIYA. 2016;26(4):421-435. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-4-421-435

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