Inhaled steroids / long6acting β2-agonists in treatment of chronic obstructive pulmonary disease: the discussion goes on
https://doi.org/10.18093/0869-0189-2016-26-3-357-363
Abstract
Chronic obstructive pulmonary disease (COPD) is an actual healthcare problem. Inflammation is a part of pathogenesis of COPD; therefore, antiinflammatory agents including inhaled corticosteroids (ICS) play an important role in therapy of this disease. Favorable effects of ICS on outcomes of COPD were confirmed, but treatment with ICS in these patients is associated with an increased risk of adverse events, particularly pneumonia. Results of clinical trials demonstrated long"term effects of ICS and long"acting β2"agonists (LABA) in patients with different stages of COPD. Efficacy and safety of novel fluticasone furoate / vilanterol once"daily combination have been discussed in this review. Data on pneumonia as the most troubling adverse effect of ICS / LABA treatment and recent evidence on class specificity of this effect have been reviewed. Blood eosinophilia is considered as a biomarker that potentially could distinguish patients who would have more benefit from ICS prescription.
About the Authors
E. N. Barabanova
GlaxoSmithKline Trading PLC: 17, build. 3, Krylatskaya str., Moscow, 121614, Russia
Russian Federation
Russian Federation
PhD, Medical and Scientific Communication Manager, GlaxoSmithKline Trading PLC; tel.: (495) 7778900
Y. M. Kolontareva
GlaxoSmithKline Trading PLC: 17, build. 3, Krylatskaya str., Moscow, 121614, Russia
Russian Federation
Russian Federation
Respiratory Medical Affairs Manager, GlaxoSmithKline Trading PLC; tel.: (495) 7778900
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Review
For citations:
Barabanova E.N., Kolontareva Y.M. Inhaled steroids / long6acting β2-agonists in treatment of chronic obstructive pulmonary disease: the discussion goes on. PULMONOLOGIYA. 2016;26(3):357-363. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-3-357-363
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