A novel diagnostic principle for alveolar6capillary membrane permeability disorders
https://doi.org/10.18093/0869-0189-2016-26-3-340-344
Abstract
The aim of this study was to estimate the diffusing capacity of the alveolar"capillary membrane (Dm) and the alveolar volume of the lungs (Va) based on measured CO concentration and basic spirometric parameters.
Methods. Previously, we calculated CO concentration in the exhaled air during tidal and forced breathing. Experimental data of a healthy volunteer were analyzed with presumable predicted values of Dm = 60 and Va = 7.0. Then, the real Dm and Va were estimated.
Results. We determined an equation for the present case (male; 176 cm of height; 50 years of age). This equation was too intricate for the routine use, so we developed an online calculator to estimate values in the real"time regimen on the basis of DELPHI platform.
Conclusion. Our findings could make reasonability for further investigation to develop a new method for Dm and Va estimation that could be more feasible because it do not need test gas mixtures.
About the Authors
E. V. Babarskov
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
PhD in Engineering, Chief Scientist at Laboratory of Functional and Ultrasound Investigations; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (495) 3965309
A. P. Mazurik
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
freelance information technology consultant of Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (910) 4445376
A. V. Chernyak
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Division of Clinical Physiology and Clinical Trials, Federal Institution “Pulmonology Research Institute”, Federal Medical and Biological Agency of Russia; tel.: (495) 9653466
Z. R. Aysanov
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
PhD, Head of Laboratory of Functional and Ultrasound Investigations; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel.: (495) 4655384
A. G. Chuchalin
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
MD, Professor, Academician of Russian Science Academy, Director of Federal Institution “Pulmonology Research Institute”, Federal Medical and Biological Agency of Russia; tel.: (495) 4655264
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Review
For citations:
Babarskov E.V., Mazurik A.P., Chernyak A.V., Aysanov Z.R., Chuchalin A.G. A novel diagnostic principle for alveolar6capillary membrane permeability disorders. PULMONOLOGIYA. 2016;26(3):340-344. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-3-340-344
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