Nontuberculous mycobacteria in patients with respiratory diseases (a clinical study)
https://doi.org/10.18093/0869-0189-2016-26-3-303-308
Abstract
The aim of this study was to analyze medical reports of patients treated at the Federal Central Research Institute of Tuberculosis in 2011 to 2014.
Methods. One hundred of medical reports have been analyzed. Nontuberculosis mycobacteria (NTM) were searched in sputum, bronchoalveolar lavage fluid or resected tissue samples. Microscopy of samples stainedmatographic rapid test for Mycobacterium tuberculosis complex antigen detection were used. Nontuberculous mycobacteriosis was diagnosed according to ATS criteria.
Results. The patients were 20 to 78 years of age. Most patients had pulmonary tuberculosis (44%) and chronic non"specific inflammatory respiratory diseases (45%). Common clinical symptoms were cough (98.2%), dyspnea (72.4%), haemophtysis (10.3%), fatigue (68.5%), loss of appetite (32.3%), and weight loss (12.5%). Radiological signs were in line with the underlying disease and were as follows: pulmonary nodules (6%), disseminated lesions (6%), tuberculomas (7%), cavities (12%), pulmonary infiltrates (8%), bullae (42%), ground glass opacities (5%), honeycombing (2%, bronchiectasis (20%), intrathoracic lymph node enlargement (5%), cirrhotic pulmonary lesions (19%), and combination of various radiological signs (32%).
Conclusion. Patients with chronic respiratory diseases, such as chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, pneumoconiosis. etc.; patients on long"term therapy with systemic steroids, patients with pulmonary tuberculosis or with a history of pulmonary tuberculosis are at risk of having nontuberculous mycobacteriosis.
About the Authors
A. E. Ergeshov
Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy: 2, Yauzskaya walk, Moscow, 107564, Russia
Russian Federation
Russian Federation
MD, Professor, Director of Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy; tel.: (909) 6284530
E. I. Shmelev
Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy: 2, Yauzskaya walk, Moscow, 107564, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Department of Differentiated Diagnostics of Tuberculosis, Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy; tel.: (903)
1923274
M. N. Kovalevskaya
Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy: 2, Yauzskaya walk, Moscow, 107564, Russia
Russian Federation
Russian Federation
PhD, Head of Clinical Department, Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy; tel.: (903) 7576508
E. E. Larionova
Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy: 2, Yauzskaya walk, Moscow, 107564, Russia
Russian Federation
Russian Federation
PhD in Biology, Senior Researcher at Laboratory of Microbiology, Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy; tel.: тел.: (499) 7859091
L. N. Chernousova
Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy: 2, Yauzskaya walk, Moscow, 107564, Russia
Russian Federation
Russian Federation
Doctor in Biology, Professor, Head of Laboratory of Microbiology, Federal Central Research Institute of Tuberculosis, Russian Medical Science Academy; tel.: тел.: (499) 7859091
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Review
For citations:
Ergeshov A.E., Shmelev E.I., Kovalevskaya M.N., Larionova E.E., Chernousova L.N. Nontuberculous mycobacteria in patients with respiratory diseases (a clinical study). PULMONOLOGIYA. 2016;26(3):303-308. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-3-303-308
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