Model of mucociliary clearance of the lung
https://doi.org/10.18093/0869-0189-2016-26-2-222-230
Abstract
The aimof this study was development of a model of the lung clearance in order to test an accordance of current sanitary regulations to recent view on mucociliary clearance capacity. Methods. We used a statistical morphometric model of the tracheobronchial tree. The model parameters were chosen to fit for experiments on slowly clearance of the lungs from calibrated-size aerosols. Results. The improved model of the tracheobronchial tree permits assessment of the maximal mass transported by the mucociliary escalator. An accumulation phase has been found which is due to a lack of time for the airway clearance in subjects regularly exposed to the air dust. Moreover, dust exposure standardization should consider not only the air pollution level but duration of pollutant air exposure and time intervals between shifts. The latter should be long enough to eliminate dust particles out of deep (in accordance to the particle size) parts of the tracheobronchial tree.
Conclusion. These data could be useful for determination of acceptable air pollution and shift work scheduling.
About the Author
G. V. Fedorovich
LLC "NTM-Zashchita": 22, build. 4/7, Kashirskoe av., Moscow, 115201, Russia
Russian Federation
Russian Federation
Doctor in Physics & Mathematics, Researcher at LLC «NTM-Zashchita»; tel.: (495) 500-03-00;
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Review
For citations:
Fedorovich G.V. Model of mucociliary clearance of the lung. PULMONOLOGIYA. 2016;26(2):222-230. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-2-222-230
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