Противовоспалительный фактор слизистых – секретоглобин SCGB1A1
Аннотация
Секретоглобин SCGB1A1 – белок, синтезируемый секреторными клетками эпителия воздухоносных путей (клубными клетками, или клетками Клара), а также другими эпителиальными клетками дыхательного и урогенитального тракта. Семейство секретоглобинов участвует в обеспечении гомеостаза при окислительном повреждении, воспалении, аутоиммунных процессах и канцерогенезе. Первый член семейства – секретоглобин SCGB1A1 – многофункциональный белок с выраженными противовоспалительными, иммуномодулирующими свойствами. В дополнение к его противовоспалительной функции он также проявляет антихемотактические, противоаллер гические, противоопухолевые свойства, а также оказывает ростостимулирующий эффект на преимплантированный эмбрион. Генетический полиморфизм гена SCGB1A1 связан с частотой развития ряда воспалительных и аутоиммунных заболеваний. Эти свойства предполагают возможность его использования для диагностики и лечения воспалительных, аутоиммунных и аллергических заболеваний.
Ключевые слова
Об авторах
Н. К. Малая
ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского": 295006, Россия, Республика Крым, Симферополь, бр Ленина, 5 / 7
Россия
Россия
аспирант кафедры педиатрии с курсом физиотерапии ФПО ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского"; тел.: (978) 8483121
Н. Н. Каладзе
ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского": 295006, Россия, Республика Крым, Симферополь, бр Ленина, 5 / 7
Россия
Россия
д. м. н., профессор, зав. кафедрой педиатрии с курсом физиотерапии ФПО ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского"; тел.: 38 (0652) 276626
К. Д. Малый
ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского": 295006, Россия, Республика Крым, Симферополь, бр Ленина, 5 / 7
Россия
Россия
к. м. н., ст. преподаватель кафедры биофизики ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского"; тел.: (978) 8483117
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Рецензия
Для цитирования:
Малая Н.К., Каладзе Н.Н., Малый К.Д. Противовоспалительный фактор слизистых – секретоглобин SCGB1A1. Пульмонология. 2015;25(4):492-496. https://doi.org/10.18093/0869-0189-2015-25-4-492-496
For citation:
Malaya N.K., Kaladze N.N., Malyy K.D. Mucosal anti6inflammatory factor secretoglobin SCGB1A1. PULMONOLOGIYA. 2015;25(4):492-496. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-4-492-496
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