Pneumonia from the point of view of organ interaction
https://doi.org/10.18093/0869-0189-2015-25-4-483-491
Abstract
Functional interaction between parenchyma components, stroma, and hematopoietic cell populations of the alveoli under acute inflammation have been described in this review. Cells interact via cytokines and growth factors; a role of this interaction for the pathogenesis of pneumonia is also discussed. We suppose a need of omprehensive research of pneumonia pathogenesis in terms of all structural components of inflammation focus. Thereafter we introduced a concept of interaction systems. Parenchymal elements, such as type I and type II pneumocytes, brush cells, and stromal elements, such as interstitial tissue, fibers, cell populations, alveolar capillaries, and autonomic nerve terminals, are describes in the article. Certain aspects of pneumonia pathogenesis are poorly understood including mechanisms of neutrophil migration to the alveoli and a role of interaction systems in this process. We offer to apply the term of interaction systems relating to the lung tissue when investigating pneumonia.
About the Authors
R. F. Zibirov
Smolensk State Medical University, Healthcare Ministry of Russia: 28, Krupskoy str., Smolensk, 214019, Russia
State Regional Smolensk Institute of Pathology: 27, Gagarina av., Smolensk, 214018, Russia
Russian Federation
Russian Federation
Assistant Lecturer at Department of Pathological Anatomy, Smolensk State Medical University, Healthcare Ministry of Russia; pathologist at the Division of Clinical Pathology N2, State Regional Smolensk Institute of Pathology; tel.: (4812) 383102
D. V. Kozlov
Smolensk State Medical University, Healthcare Ministry of Russia: 28, Krupskoy str., Smolensk, 214019, Russia
State Regional Smolensk Institute of Pathology: 27, Gagarina av., Smolensk, 214018, Russia
Russian Federation
Russian Federation
MD, Professor at Department of Pathological Anatomy, Smolensk State Medical University, Healthcare Ministry of Russia; Head of the Division of Clinical Pathology N2, State Regional Smolensk Institute of Pathology; tel.: (4812) 383102
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For citations:
Zibirov R.F., Kozlov D.V. Pneumonia from the point of view of organ interaction. PULMONOLOGIYA. 2015;25(4):483-491. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-4-483-491
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