Взгляд на пневмонию с позиции коммуникационных систем


https://doi.org/10.18093/0869-0189-2015-25-4-483-491

Полный текст:


Аннотация

Данный обзор литературы посвящен функциональным особенностям взаимодействия между компонентами паренхимы, стромы, гематогенными клеточными популяциями в легочной альвеоле при развитии острого воспаления. Показано взаимное влияние клеток через цитокины, факторы роста и роль этого влияния на патогенез пневмонии. Обсуждается необходимость комплексного изучения патогенеза пневмонии с акцентом на всех структурных компонентах очага воспаления, в связи с чем используется понятие о коммуникационных системах. В работе описаны элементы паренхимы (пневмоциты 1го и 2го порядка, щеточные клетки) и стромы (основное межуточное вещество, волокна и клеточные популяции, альвеолярные капилляры легких, вегетативные нервные терминали). Обращается внимание на недостаточно изученные аспекты патогенеза пневмоний – механизмы миграции нейтрофильных лейкоцитов в легочную альвеолу и роль компонентов коммуникационных систем в этом процессе. Предлагается использовать понятие о коммуникационных системах применительно к легочной ткани при исследовании пневмонии.


Об авторах

Р. Ф. Зибиров
ГБОУ ВПО "Смоленский государственный медицинский университет" Минздрава России; 214019, Смоленск, ул. Крупской, 28 ОГБУЗ "Смоленский областной институт патологии": 214018, Смоленск, проспект Гагарина, 27
Россия

ассистент кафедры патологической анатомии ГБОУ ВПО "Смоленский государственный медицинский университет" Минздрава России, врачпатологоанатом отделения клинической патологии № 2 ОГБУЗ "Смоленский областной институт патологии"; тел.: (4812) 383102



Д. В. Козлов
ГБОУ ВПО "Смоленский государственный медицинский университет" Минздрава России; 214019, Смоленск, ул. Крупской, 28 ОГБУЗ "Смоленский областной институт патологии": 214018, Смоленск, проспект Гагарина, 27
Россия

д. м. н., профессор кафедры патологической анатомии ГБОУ ВПО "Смоленский государственный медицинский университет" Минздрава России, зав. отделением клинической патологии № 2 областного государственного бюджетного учреждения здравоохранения "Смоленский областной институт патологии"; тел.: (4812) 383102



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Дополнительные файлы

Для цитирования: Зибиров Р.Ф., Козлов Д.В. Взгляд на пневмонию с позиции коммуникационных систем.  Пульмонология. 2015;25(4):483-491. https://doi.org/10.18093/0869-0189-2015-25-4-483-491

For citation: Zibirov R.F., Kozlov D.V. Pneumonia from the point of view of organ interaction. Russian Pulmonology. 2015;25(4):483-491. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-4-483-491

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ISSN 0869-0189 (Print)
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