Modern inhalation drug delivery devices for treatment of chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2015-25-4-477-482
Abstract
This review includes history of development of devices for drug delivery to the airways. Currently, there is a large diversity of different drug delivery devices for inhalation therapy of chronic obstructive pulmonary disease (COPD): pressurized metered dosing aerosol inhalers (activated or not activated by breath), dry powder nhalers (single dose or multiple dose), jet nebulizers, ultrasound nebulizers and soft mist inhalers. This wide spectrum of different inhalation drug delivery devices provides an improvement in treatment of various respiratory diseases, primarily COPD, due to individual choice of an inhaler considering the patient's age, comorbidity and severity of the disease.
About the Authors
N. T. Vatutin
M.Gor'kiy Donetsk National State Medical University: 16, Il'icha av., Donetsk, 83003, Ukraine
V.K.Gusak State Institute of Urgent and Reconstructive Surgery, National Medical Science Academy of Ukraine: 47, Leninskiy av., Donetsk, 83000, Ukraine
Russian Federation
Russian Federation
MD, Professor, Head of Department of Internal Diseases N1, M.Gor'kiy Donetsk National State Medical University; tel.:
(38062) 3850517
A. S. Smirnova
M.Gor'kiy Donetsk National State Medical University: 16, Il'icha av., Donetsk, 83003, Ukraine
Russian Federation
Russian Federation
PhD, Assistant Lecturer at Department of Internal Diseases N1, M.Gor'kiy Donetsk National State Medical University; tel.: (38062) 3850517
G. G. Taradin
M.Gor'kiy Donetsk National State Medical University: 16, Il'icha av., Donetsk, 83003, Ukraine
Russian Federation
Russian Federation
PhD, Associate Professor at Department of Internal Diseases N1, M.Gor'kiy Donetsk National State Medical University; tel.: (38062) 3850517
References
1. Global Initiative for Chronic Obstructive lung Disease (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI / WHO workshop report. Updated 2013. www.gold copd.com
2. Vatutin N.T., Smirnova A.S. Chronic Obstructive Pulmonary Disease: guidelines, 2013. Arkhіv klіnіchnoї ta eksperimental'noї meditsini. 2014; 2: 217–223 (in Russian).
3. Crompton G.K., Barnes P.J., Broeders M. et al. The need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement Team. Respir. Med. 2006; 100:1479–1494.
4. Papi A., Haughney J., Virchow J.C. et al. Inhaler devices for asthma: a call for action in aneglected field. Eur. Respir. J. 2011; 37: 982–985.
5. Crompton G.K. A brief history of inhaled asthma therapy over the last fifty years. Prim. Care Respir. J. 2006; 15 (6):326–331.
6. Polyanskaya M.A., Lekan O.Ya., Tumanov A.N. et al. Modern inhalation drug delivery devices for asthma control achievement. Astma ta alergіya. 2002; 1: 27–32 (in Russian).
7. Crompton G.K. Problems patients have using pressurized aerosol inhalers. Eur. J. Respir. Dis. 1982; 63 (Suppl. 119): 101–104.
8. Salvi S., Gogtay J., Aggarwal B. Use of breath actuated inhalers in patients with asthma and COPD – an advance in inhalational therapy: a systematic review. Exp. Rev. Respir. Med. 2014; 8 (1): 89–99.
9. Bell J.H., Hartley P.S., Cox J.S. Dry powder aerosols. A new powder inhalation device. J. Pharm. Sci. 1971; 60 (10): 1559–1564.
10. Molimard M., D'Andrea P. Once daily glycopyrronium via the Breezhaler® device for the treatment of COPD: pharmacological and clinical profile. Exp. Rev. Clin. Pharmacol. 2013; 6 (5): 503–517.
11. Atkins P.J. Dry powder inhalers: an overview. Respir. Care. 2005; 50 (10): 1304–1312.
12. Everard M.L., Devadason S.G., Le Souef P.N. Flow early in the inspiratory manoeuvre affects the aerosol particle size distribution from a Turbuhaler. Respir. Med. 1997; 91 (10): 624–628.
13. Pover G.M., Langdon C.G., Jones S.R. et al. Evaluation of a breath operated powder inhaler. J. Int. Med. Res. 1988; 16 (3): 201–203.
14. Chrystyn H. The Diskus™: a review of its position among dry powder inhaler devices. Int. J. Clin. Pract. 2007; 61 (6):1022–1036.
15. Feshchenko Yu.I., Yashina L.A., Tumanov A.N. et al. Use of nebulizers in clinical practice. Astma ta alergіya. 2006; 3–4: 59–70 (in Russian).
16. Gillissen A. Novel drugs for COPD treatment. MMW Fortschr. Med. 2014; 156 (14): 68–69, 71.
17. Laube B.L., Janssens H.M., Jongh F.H.C. et al. What the pulmonary specialist should know about the new inhalation therapies. Eur. Respir. J. 2011; 37: 1308–1331.
18. Keating G.M. Tiotropium Respimat® Soft Mist™ Inhaler: A review of its use in chronic obstructive pulmonary disease. Drugs. 2014; 74 (15): 1801–1816.
Review
For citations:
Vatutin N.T., Smirnova A.S., Taradin G.G. Modern inhalation drug delivery devices for treatment of chronic obstructive pulmonary disease. PULMONOLOGIYA. 2015;25(4):477-482. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-4-477-482
Views:
999
Email this article 