Combination therapy with bisoprolol and amlodipine in patients with chronic obstructive pulmonary disease and hypertension
https://doi.org/10.18093/0869-0189-2015-25-4-440-446
Abstract
The purpose of this study was to assess efficacy of a fixed combination of bisoprolol and amlodipine (Concor AM, Takeda) in patients with chronic obstructive pulmonary disease (COPD) and hypertension (H).
Methods. Thirty eight stable patients with stage 2 COPD and stage I–II H were treated with a fixed combination of bisoprolol and amlodipine. 24h ambulatory blood pressure monitoring (ABPM), electrocardiography, echocardiography, and lung function were performed at the baseline and in 12 weeks of therapy.
Results. Thirty four (89.5%) patients continued the treatment after 12 weeks. The therapy with the fixed combination of bisoprolol and amlodipine in average dose of 7.5 / 10 mg/day provided a target blood pressure (BP) level in 32 (84.2%) patients. ABPM analysis demonstrated stable significant improvement in BP parameters including the heart rate variability. A trend toward normalization of the left heart diastolic function was noted during treatment. Lung function did not differ significantly before and after 12 weeks of the treatment indicating that the fixed combination of bisoprolol and amlodipine did not impact negatively on bronchial obstruction.
Conclusion. The results confirm the rationale of therapy with the fixed combination of bisoprolol and amlodipine in patients COPD
and H.
About the Authors
V. A. Nikitin
State Institution "N.N.Burdenko Voronezh State Medical Academy", Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia
Russian Federation
Russian Federation
PhD, Assistant Lecturer at the Department of Therapy, State Institution "N.N.Burdenko Voronezh State Medical Academy", Healthcare Ministry of Russia; tel.: (920) 4147652
E. V. Gosteva
State Institution "N.N.Burdenko Voronezh State Medical Academy", Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia
Voronezh City Clinical Hospital N20: 15, Deputatskaya str., Voronezh, 394055, Russia
Russian Federation
Russian Federation
PhD, Associate Professor at the Department of Propaedeutics of Internal Diseases, State Institution "N.N.Burdenko Voronezh State Medical Academy", Healthcare Ministry of Russia; function al diagnostics specialist at the Voronezh City Clinical Hospital N20; tel.: (910) 3485797
L. V. Pyshnograeva
Voronezh City Clinical Hospital N20: 15, Deputatskaya str., Voronezh, 394055, Russia
Russian Federation
Russian Federation
PhD, Deputy Chief Medical Officer, cardiologist at the Voronezh City Clinical Hospital N20; tel.: (473) 2368020
L. V. Vasil'eva
State Institution "N.N.Burdenko Voronezh State Medical Academy", Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Department at the Department of Therapy, State Institution "N.N.Burdenko Voronezh State Medical Academy", Healthcare Ministry of Russia; tel.: (910) 3473687
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Review
For citations:
Nikitin V.A., Gosteva E.V., Pyshnograeva L.V., Vasil'eva L.V. Combination therapy with bisoprolol and amlodipine in patients with chronic obstructive pulmonary disease and hypertension. PULMONOLOGIYA. 2015;25(4):440-446. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-4-440-446
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