Osteoplastic pneumopathy as epithelial-mesenchymal transformation and pneumoconiosis (analytical review and own observations)
https://doi.org/10.18093/0869-0189-2015-25-3-378-383
Abstract
This is a review of published data on pulmonary ossification and a description of case report of a miner with pulmonary ossification considered as a manifestation of pneumoconiosis. Diagnosis was confirmed by immunohistochemical investigation of lung biopsy specimens that revealed epithelial-mesenchymal transformation. Foci of pulmonary fibrosis with bone tissue accumulation, periosteal coal dust accumulation and heterotopic type of ossification suggesting an excessive morphogenic response of fibroblastic phenotype cells that is a typical sign of pneumoconiosis were considered as ossification which in turn was a manifestation of pneumoconiosis. The presence of vimentin as a marker of the less differentiated mesenchymal cells showed that fibrosis was related neither to resident progenitor cells nor circulating bone marrow stem cells but to specialized bronchial epithelium cells with changed phenotype.
About the Authors
O. I. Bondarev
State Institution «Novokuznetsk State Institute of Physician Postgraduate Education», Healthcare Ministry of Russia: 5, av. Stroiteley, Kemerovо reg., Novokuznetsk, 654005, Russia
Russian Federation
Russian Federation
PhD, Associate Professor at Department of Pathologic Anatomy and Forensic Pathology, State Institution «Novokuznetsk State Institute of Physician Postgraduate Education», Healthcare Ministry of Russia; tel.: (3843) 45-56-41; факс: (384-3) 45-42-19;
V. V. Razumov
State Institution «Novokuznetsk State Institute of Physician Postgraduate Education», Healthcare Ministry of Russia: 5, av. Stroiteley, Kemerovо reg., Novokuznetsk, 654005, Russia
Russian Federation
Russian Federation
MD, Professor, Associate Member of Russian Academy of Natural Science, Head of Department of Occupational Diseases, State Institution «Novokuznetsk State Institute of Physician Postgraduate Education», Healthcare Ministry of Russia; tel. / fax: (3843) 79-65-26;
A. L. Khanin
State Institution «Novokuznetsk State Institute of Physician Postgraduate Education», Healthcare Ministry of Russia: 5, av. Stroiteley, Kemerovо reg., Novokuznetsk, 654005, Russia
Russian Federation
Russian Federation
PhD, Professor, Head of Department of Phthisiology and Pulmonology,State Institution «Novokuznetsk State Institute of Physician Postgraduate Education», Healthcare Ministry of Russia; Honorary Physician of Russian Federation; tel.: (3843) 45-56-41; fax: (384-3) 45-42-19;
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Review
For citations:
Bondarev O.I., Razumov V.V., Khanin A.L. Osteoplastic pneumopathy as epithelial-mesenchymal transformation and pneumoconiosis (analytical review and own observations). PULMONOLOGIYA. 2015;25(3):378-383. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-3-378-383
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