Osteoplastic pneumopathy as epithelial-mesenchymal transformation and pneumoconiosis (analytical review and own observations)

O. I. Bondarev; V. V. Razumov; A. L. Khanin

doi:10.18093/0869-0189-2015-25-3-378-383

Osteoplastic pneumopathy as epithelial-mesenchymal transformation and pneumoconiosis (analytical review and own observations)

O. I. Bondarev, V. V. Razumov, A. L. Khanin

https://doi.org/10.18093/0869-0189-2015-25-3-378-383

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Abstract

This is a review of published data on pulmonary ossification and a description of case report of a miner with pulmonary ossification considered as a manifestation of pneumoconiosis. Diagnosis was confirmed by immunohistochemical investigation of lung biopsy specimens that revealed epithelial-mesenchymal transformation. Foci of pulmonary fibrosis with bone tissue accumulation, periosteal coal dust accumulation and heterotopic type of ossification suggesting an excessive morphogenic response of fibroblastic phenotype cells that is a typical sign of pneumoconiosis were considered as ossification which in turn was a manifestation of pneumoconiosis. The presence of vimentin as a marker of the less differentiated mesenchymal cells showed that fibrosis was related neither to resident progenitor cells nor circulating bone marrow stem cells but to specialized bronchial epithelium cells with changed phenotype.

Keywords

pulmonary ossification, pneumoconiosis, epithelial-mesenchymal transformation, vimentin

References

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For citations:

Bondarev O.I., Razumov V.V., Khanin A.L. Osteoplastic pneumopathy as epithelial-mesenchymal transformation and pneumoconiosis (analytical review and own observations). PULMONOLOGIYA. 2015;25(3):378-383. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-3-378-383

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PULMONOLOGIYA

Osteoplastic pneumopathy as epithelial-mesenchymal transformation and pneumoconiosis (analytical review and own observations)

Full Text:

Abstract

Keywords

About the Authors

References

Review

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PULMONOLOGIYA

Osteoplastic pneumopathy as epithelial-mesenchymal transformation and pneumoconiosis (analytical review and own observations)

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

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