Primary spontaneous pneumothorax and connective tissue dysplasia: clinical and morphological parallels
https://doi.org/10.18093/0869-0189-2015-25-3-340-349
Abstract
The objective of this study was to define pathologic mechanisms of primary spontaneous pneumothorax in patients with connective tissue dysplasia (CTD). Methods. We followed-up 42 young patients with CTD and bullous emphysema in the lung CT without history of primary spontaneous pneumothorax. Results of clinical, functional, radiological and molecular testing were compared with morphological examination of resected lung tissue specimens from 165 patients underwent lung surgery for primary spontaneous pneumothorax. Results. Two mechanisms underlying emphysema in CTD patients were defined. Conclusion: The results supported a hypothesis of causative relationship between congenital CTD and bullous emphysema in young patients.
About the Authors
M. V. Vershinina
State Institution “Omsk State Medical University”, Healthcare Ministry of Russia; 12 Lenina str., Omsk, 644043, Russia;
Russian Federation
Russian Federation
PhD, Associate Professor at the Department of Internal Medicine and Family Medicine, State Institution “Omsk State Medical University”, Healthcare Ministry of Russia; tel. / fax: (3812) 23-67-00;
L. M. Grinberg
State Institution “Ural State Medical University”, Healthcare Ministry of Russia; 3 Repina str., Ekaterinburg, 620028, Russia;
Federal Institution “Ural Research Institute of Phthisiopulmonology”, Healthcare Ministry of Russia; 50 22-go Parts"ezda str., Ekaterinburg, 620039, Russia;
Russian Federation
Russian Federation
MD, Professor, Head of Department of Pathological Anatomy, State Institution “ Ural State Medical University”, Healthcare Ministry of Russia; tel. / fax: (343) 371-34-90;
G. I. Nechaeva
State Institution “Omsk State Medical University”, Healthcare Ministry of Russia; 12 Lenina str., Omsk, 644043, Russia;
Russian Federation
Russian Federation
MD, Professor, Head of Department of Internal Medicine and Family Medicine, State Institution “Omsk State Medical University”, Healthcare Ministry of Russia; tel. / fax: (3812) 23-67-00;
A. S. Filatova
State Institution “Ural State Medical University”, Healthcare Ministry of Russia; 3 Repina str., Ekaterinburg, 620028, Russia;
Russian Federation
Russian Federation
PhD, Associate Professor at the Department of Pathological Anatomy, State Institution “Ural State Medical University”, Healthcare Ministry of Russia; tel. / fax:: (343) 371-34-90;
A. V. Neretin
Federal Institution “Ural Research Institute of Phthisiopulmonology”, Healthcare Ministry of Russia; 50 22-go Parts"ezda str., Ekaterinburg, 620039, Russia;
Russian Federation
Russian Federation
PhD, Senior Researcher, Federal Institution “Ural Research Institute of Phthisiopulmonology”, Healthcare Ministry of Russia; tel. / fax: (343) 333-44-63;
A. A. Khomenya
State Institution “Omsk State Medical University”, Healthcare Ministry of Russia; 12 Lenina str., Omsk, 644043, Russia;
Russian Federation
Russian Federation
PhD, Teacher at Central Medical Commission on Therapy, College at the State Institution “Omsk State Medical University”, Healthcare Ministry of Russia; pulmonologist; tel. / fax: (3812) 23-67-00;
S. E. Govorova
Budget Institution “A.N.Kabanov City Clinical Hospital N1”; 7 Pereleta str., Omsk, 644000, Russia
Russian Federation
Russian Federation
PhD, therapeutist at the Budget Institution “A.N.Kabanov City Clinical Hospital N1”; tel. (3812) 23-67-00;
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Review
For citations:
Vershinina M.V., Grinberg L.M., Nechaeva G.I., Filatova A.S., Neretin A.V., Khomenya A.A., Govorova S.E. Primary spontaneous pneumothorax and connective tissue dysplasia: clinical and morphological parallels. PULMONOLOGIYA. 2015;25(3):340-349. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-3-340-349
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