A role of the osteopontin for development of right heart diastolic dysfunction in patients with atopic bronchial asthma
https://doi.org/10.18093/0869-0189-2015-25-3-333-339
Abstract
The purpose of this study was to investigate a role of osteopontin for development of right heart diastolic dysfunction in patients with atopic bronchial asthma (ABA). This is important for early diagnosis of pulmonary hemodynamic disorders. Methods. The study involved 188 subjects: 148 ABA patients who were divided into 3 groups according to asthma severity and 40 healthy volunteers as controls. We measured right ventricle functional parameters and blood osteopontin concentration. Results. While increasing ABA severity blood osteopontin concentration increased and the right ventricle diastolic function decreased in comparison to the healthy controls. Osteopontin concentration was higher in patients with right heart dysfunction. Conclusion: More severe course of ABA was associated with higher blood osteopontin concentration. More significant right heart dysfunction was seen in patients with moderate to severe ABA. Right heart dysfunction in ABA was associated with systemic inflammation, particularly with osteopontin concentration.
About the Authors
I. A. Solov'eva
State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Russian Federation
Russian Federation
PhD, Assistant Lecturer, Department of Internal Medicine N2, State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; tel.: (913) 835-26-43;
A. Yu. Kraposhina
State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Russian Federation
Russian Federation
PhD, Assistant Lecturer, Department of Internal Medicine N2, State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; tel.: (902) 990-37-67;
E. A. Sobko
State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Territorial Institution “Territorial clinical hospital”; 3а, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia
Russian Federation
Russian Federation
MD, Associate Professor at the Department of Internal Medicine N2, State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; tel.: (923) 327-11-92;
I. V. Demko
State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russia;
Russian Federation
Russian Federation
MD, Professor, Head of Department of Internal Medicine N2, State Institution "V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University", Healthcare Ministry of Russia; tel.: (913) 507-84-08;
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Review
For citations:
Solov'eva I.A., Kraposhina A.Yu., Sobko E.A., Demko I.V. A role of the osteopontin for development of right heart diastolic dysfunction in patients with atopic bronchial asthma. PULMONOLOGIYA. 2015;25(3):333-339. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-3-333-339
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