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PULMONOLOGIYA

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Genealogy data analysis in adults with primary immunodeficiency

https://doi.org/10.18093/0869-0189-2015-25-2-205-210

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Abstract

This study was aimed at analysis of pedigrees of adult patients with primary immunodeficiency (PID). Methods. We examined 94 adults with primary immunodeficiency and 217 adults without this disease. Genealogy analysis was made at least for four generations in all patients. Results. Relatives of most PID patients (75 %) had autoimmune disorders. Relatives of near all (99 %) of PID patients had allergic diseases. Sixty nine per cent of PID patients had cases of infant death due to infectious or oncological diseases in ancestors. Conclusion. Genealogy analysis of patients with confirmed or suspected PID could be an important diagnostic measure. Data about relatives with atypical infectious, inflammatory or autoimmune diseases are the most valuable.

For citations:


Karakina M.L., Shershnev V.N., Tuzankina I.A. Genealogy data analysis in adults with primary immunodeficiency. PULMONOLOGIYA. 2015;25(2):205-210. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-2-205-210

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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)