Genealogy data analysis in adults with primary immunodeficiency
https://doi.org/10.18093/0869-0189-2015-25-2-205-210
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Abstract
This study was aimed at analysis of pedigrees of adult patients with primary immunodeficiency (PID). Methods. We examined 94 adults with primary immunodeficiency and 217 adults without this disease. Genealogy analysis was made at least for four generations in all patients. Results. Relatives of most PID patients (75 %) had autoimmune disorders. Relatives of near all (99 %) of PID patients had allergic diseases. Sixty nine per cent of PID patients had cases of infant death due to infectious or oncological diseases in ancestors. Conclusion. Genealogy analysis of patients with confirmed or suspected PID could be an important diagnostic measure. Data about relatives with atypical infectious, inflammatory or autoimmune diseases are the most valuable.
About the Authors
M. L. KarakinaRussian Federation
PhD, Researcher, Federal Institution "Institute of Immunology and Physiology", Ural Department of Russian Academy of Medical Science; an immunologist of the State Institution "Regional Pediatric Clinical Hospital N1" and State Institution "Sverdlovsk Regional Clinilcal Hospital N1"; tel.: (343) 351-16-62;
V. N. Shershnev
Russian Federation
PhD in Physics and Mathematics, Head of Laboratory of Systemic Analysis, Federal Institution "Institute of Industrial Ecology", Ural Department of Russian Academy of Medical Science; tel.: (343) 249-33-93;
I. A. Tuzankina
Russian Federation
MD, Professor, Chief Scientist, Federal Institution "Institute of Immunology and Physiology", Ural Department of Russian Academy of Medical Science; Head of the Regional Center of Clinical Immunology, State Institution "Regional Pediatric Clinical Hospital N1", Chief Immunologist of Healthcare Ministry at Sverdlovsk region; tel.: (343) 272-08-23,
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Review
For citations:
Karakina M.L., Shershnev V.N., Tuzankina I.A. Genealogy data analysis in adults with primary immunodeficiency. PULMONOLOGIYA. 2015;25(2):205-210. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-2-205-210
ISSN 2541-9617 (Online)