Antioxidant effect of ambroxol in acute exacerbation of chronic obstructive pulmonary disease in obese patients
https://doi.org/10.18093/0869-0189-2015-25-2-175-179
Abstract
The aim of this study was to investigate antioxidant activity and clinical efficacy of parenteral ambroxol in obese patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods. Malondialdehyde (MDA), oxidative modification of proteins (MBP) and antiradical activity of (ARA) were measured in blood sera of 98 patients with acute exacerbation of COPD and obesity and in 23 healthy subjects. MDA was measured using thiobarbituric acid. MBP was detected using interaction between oxidized amino acid residues (aldehyde and ketone groups) with 2,4-dinitrophenylhydrazine (2,4-DNPH) and formation of 2,4-dinitrophenylhydrazone. Blood serum antiradical activity was detected by spectrophotometry of epinephrine autooxidation. Patients were divided into two groups: 48 COPD patients were treated with conventional therapy (bronchodilators via nebulize, glucocorticoids, antibiotics, oxygen, if necessary, mucoactive drugs orally) and ambroxol 30 mg q.d. IV; 50 patients were treated with similar conventional therapy and saline solution IV as placebo. Results. OMB level was significantly higher in COPD patients compared to that of healthy subjects. Antiradical activity in patients with acute exacerbation of COPD was significantly lower compared to healthy subjects. Intravenous ambroxol had antioxidant activity, improved clinical manifestations of acute exacerbation of COPD and contributed to faster recovery.
About the Authors
V. A. Nikitin
State Institution “N.N.Burdenko Voronezh State Medical Academy”, Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia
Russian Federation
Russian Federation
PhD, Assistant Lecturer, Department of Therapy, Institute of Physician Training, State Institution “N.N.Burdenko Voronezh State Medical Academy”, Healthcare Ministry of Russia; tel.: (473) 236-68-31;
O. V. Karpukhina
State Institution “N.N.Burdenko Voronezh State Medical Academy”, Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia
Russian Federation
Russian Federation
Assistant Lecturer, Department of Propaedeutics of Internal Diseases, State Institution “N.N.Burdenko Voronezh State Medical Academy”, Healthcare Ministry of Russia; tel.: (473) 236-68-31;
L. V. Vasil'eva
State Institution “N.N.Burdenko Voronezh State Medical Academy”, Healthcare Ministry of Russia: 10, Studencheskaya str., Voronezh, 394622, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Department of Therapy, Institute of Physician Training, State Institution “N.N.Burdenko Voronezh State Medical Academy”, Healthcare Ministry of Russia; tel.: (473) 236-68-31;
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Review
For citations:
Nikitin V.A., Karpukhina O.V., Vasil'eva L.V. Antioxidant effect of ambroxol in acute exacerbation of chronic obstructive pulmonary disease in obese patients. PULMONOLOGIYA. 2015;25(2):175-179. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-2-175-179
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