An importance of capnography in smokers and in patients with early stage chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2015-25-2-167-174
Abstract
The aim of this study was to evaluate diagnostic value of capnography for early detection of lung function disorders in smokers. Methods. We compared results of capnography and spirometry and selected the most informative capnographic parameters in three groups of patients (n = 25 each): in non-smokers with normal spirometry, in smokers with normal spirometry and both in smokers and non-smokers with airway obstruction. Curves were obtained for continuous measurement of CO2 partial tension (PCO2) against time and volume. Results. A significant increase in the slope of capnographic alveolar phase during both tidal and deep expiration and a tendency to alveolar hyperventilation were found in obstructive patients. Similar, but less prominent results were obtained in smokers with normal spirometry. Conclusion. Capnography could be useful for early detection of lung function disorders in smokers before preceding occurrence of spirometric abnormalities (airway obstruction). PCO2 measurement against time was the most valuable parameter.
About the Authors
P. V. Struchkov
Federal Institution of Аdditional Еducation "Institute of Postgraduate Training", Federal Medical and Biological Agency of Russia: 91, Volokolamskoe av., Moscow, 123371, Russia
State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia: 16, Moskvorech'e str., Moscow, 115409, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Department of Clinical Physiology and Functional Diagnosis, Federal Institution of Аdditional Еducation "Institute of Postgraduate Training", Federal Medical and Biological Agency of Russia; Chief of the Division of Functional Diagnosis, State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia; tel.: (910) 465-59-26;
O. E. Borisova
Federal Institution of Аdditional Еducation "Institute of Postgraduate Training", Federal Medical and Biological Agency of Russia: 91, Volokolamskoe av., Moscow, 123371, Russia
State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia: 16, Moskvorech'e str., Moscow, 115409, Russia
Russian Federation
Russian Federation
Assistant Lecturer, Department of Clinical Physiology and Functional Diagnosis, Federal Institution of Аdditional Еducation "Institute of Postgraduate Training", Federal Medical and Biological Agency of Russia; a physician at the Division of Functional Diagnosis, State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia; tel.: (910) 465-59-26;
A. V. Ivanushkina
Federal Institution of Аdditional Еducation "Institute of Postgraduate Training", Federal Medical and Biological Agency of Russia: 91, Volokolamskoe av., Moscow, 123371, Russia
Russian Federation
Russian Federation
resident physician, Department of Clinical Physiology and Functional Diagnosis, Federal Institution of Аdditional Еducation "Institute of Postgraduate Training", Federal Medical and Biological Agency of Russia; tel.: (910) 465-59-26;
O. S. Tseka
State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia: 16, Moskvorech'e str., Moscow, 115409, Russia
Russian Federation
Russian Federation
MD, Professor, Hospital Chief Executive Officer, State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia; tel.: (499) 324-85-52;
A. V. Potemkin
State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia: 16, Moskvorech'e str., Moscow, 115409, Russia
Russian Federation
Russian Federation
PhD, Deputy Chief, State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia; tel.: (499) 324-85-52;
E. O. Tseka
State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia: 16, Moskvorech'e str., Moscow, 115409, Russia
Russian Federation
Russian Federation
PhD, Head of Central Outpatient Hospital, State Institution "Clinical hospital N85", Federal Medical and Biological Agency of Russia; tel.: (499) 324-85-52;
I. A. Manichev
Educational Academic and Industrial National Unitary Concern "Unitekhprom BGU": 1, Kurchatova str., Minsk, 220108, Belarus' Republik
Russian Federation
Russian Federation
PhD in Physics and Mathematics, Head of Laboratory of Spirometry Equipment Development, Educational Academic and Industrial National Unitary Concern "Unitekhprom BGU"; tel.: (37517) 398-12-12;
V. G. Shcherbitsky
Educational Academic and Industrial National Unitary Concern "Unitekhprom BGU": 1, Kurchatova str., Minsk, 220108, Belarus' Republik
Russian Federation
Russian Federation
PhD in Physics and Mathematics, Researcher, Laboratory of Spirometry Equipment Development, Educational Academic and Industrial National Unitary Concern "Unitekhprom BGU"; tel.: (37517) 398-12-12;
References
1. Boksha V.G., Karpov A.P. Investigation of respiratory function of the lungs using capnography. Terapevticheskiy arkhiv. 1972; 44 (8): 36–39 (in Russian).
2. Vinitskaya R.S., Tsuzmer T.S., Koganova N.A. Use of CO2 gas infrared analyzer for analysis of alveolar air. «Novye pribory gazovogo analiza v sovremennoy meditsine». Kazan'; 1967: 158–165 (in Russian).
3. Vinitskaya R.S., Koganova N.A. Detection of CO2 sensitivity of the respiratory center in human. Fiziologiya. SSSR. 1967; 63 (4): 450–454 (in Russian).
4. Vinitskaya R.S., Koganova N.A. Detection of blood minute circulation using re-breathing method. Byulleten' eksperimental'noy biologii i meditsiny. 1977; 2: 245–247 (in Russian).
5. Vorob'eva Z.V. Lung function in stage 0 chronic obstructive pulmonary disease. Funktsional'naya diagnostika. 2005; 2: 29–32 (in Russian).
6. Redkhammer R. A. A significance of capnography for evaluation of ventilation-perfusion ratio in the lungs. In: Functional investigation in pneumology. Leningrad; 1976: 57–61 (in Russian).
7. Yukhno A.N., Shchelkunov V.S., Gukov B.K. Use of long-term capnography in intensive care of patients with respiratory diseases. In: Collected scientific papers of the 3rd Russian National Congress on respiratory diseases. Saint-Petersburg, 1992 (in Russian).
8. West J. Respiratory Physiology. Translated from English. Moscow, Mir; 1988 (in Russian).
9. Chuchalin A.G., Avdeev S.N., Aysanov Z.R. et al. Federal guidelines on diagnosis and management of chronic obstructive pulmonary disease. Pul'monologiya. 2014; 3: 15–54 (in Russian).
10. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. GOLD; 2014.
11. Kars A.H., Bogaard J.M., Stijnen T. et al. Dead space and slope indices from the expiratory carbon dioxide tension-volume curve. Eur. Respir. J. 1997; 10: 1829–1836.
12. van Meerten R.J. Expiratory gas concentration curves for examination of uneven distribution of ventilation and perfusion in the lung. First communication: theory. Respiration. 1970; 27: 552–564.
13. You B., Peslin R., Duvivier C. et al. Expiratory capnography in asthma. Eur. Respir. J. 1994; 7: 318–323.
14. Tulou P.P. Distribution of ventilation; clinical evaluation by rapid CO2 analysis. Dis. Chest. 1966; 49: 139–146.
15. Brusasco V., Crapo R., Viegi G., eds. ATS / ERS Task force: Standartisation of lung function testing. Eur. Respir. J. 2005; 26: 720–735.
16. Sil'vestrov V.P., Semin S.N., Martsinovskiy V.Yu. Possibilities of capnography for early diagnosis of ventilatory disorders. Terapevticheskiy arkhiv. 1989; 61 (3): 91–94 (in Russian).
Review
For citations:
Struchkov P.V., Borisova O.E., Ivanushkina A.V., Tseka O.S., Potemkin A.V., Tseka E.O., Manichev I.A., Shcherbitsky V.G. An importance of capnography in smokers and in patients with early stage chronic obstructive pulmonary disease. PULMONOLOGIYA. 2015;25(2):167-174. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-2-167-174
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