Efficacy of different regimens of steroid therapy in patients with exacerbation of chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2015-25-1-58-63
Abstract
Exacerbation of chronic obstructive pulmonary disease (COPD) negatively influences on mortality, health-related quality of life and lung function decline. Systemic corticosteroids are used to treat acute exacerbations of COPD. Aim. This randomized parallel-group study was performed to evaluate short-term efficacy and safety of nebulized budesonide (n = 40) and budesonide via a dry powder inhaler (DPI) (n = 40) compared with intravenous (IV) prednisolone (n = 40) in patients with acute non-severe COPD exacerbations requiring hospitalization. Methods. The efficacy of treatment was assessed from the study entry to the Day 10. Clinical improvement was assessed according to an improvement in FEV1, FVC, FEV / FVC, Borg scale, 6-minute walking test (6-MWT), SGRQ-C and occurrence of adverse events. Results. Systemic prednisolone, budesonide DPI and nebulized budesonide improved lung function in patients with acute exacerbation of COPD. Inhaled corticosteroids did not demonstrate systemic activity compared to systemic prednisolone. Conclusion. Our study suggests that nebulized budesonide and high-dose budesonide DPI could be an alternative treatment to systemic steroids in patients with acute non-severe exacerbation of COPD.
About the Authors
P. Odonchimeg
The 3rd Central Clinical Hospital, 1, Ard Ayuush str., Ulan Bator, Mongolia;
Russian Federation
Russian Federation
PhD student, respiratory specialist, Pneumology Department, the 3rd Central Clinical Hospital; tel.: 976-998-557-89;
D. Ichinnorov
Mongolian National University of Medical Science, 3, S.Zorigiyn str., Ulan Bator, 210648, Mongolia
Russian Federation
Russian Federation
PhD, Assistant Professor of the Chair of Pneumology, Medical Faculty, Mongolian National University of Medical Science; tel.: 976-999-715-61;
Zh. Sarantuyaa
Mongolian National University of Medical Science, 3, S.Zorigiyn str., Ulan Bator, 210648, Mongolia
Russian Federation
Russian Federation
PhD, Head of Chair of Cell Biology and Genetics, Faculty of Pharmacia and Bionedicine, Mongolian National University of Medical Science, tel.: 976-990-927-71;
Ts. Tumur-Ochir
The 3rd Central Clinical Hospital, 1, Ard Ayuush str., Ulan Bator, Mongolia;
Russian Federation
Russian Federation
PhD, Head of the 3rd Central Clinical Hospital, consultant of Pneumology Department, tel.: 976-990-372-27;
G. Choyzhamts
Mongolian National University of Medical Science, 3, S.Zorigiyn str., Ulan Bator, 210648, Mongolia
Russian Federation
Russian Federation
PhD, Professor of Chair of Clinical Pharmacology, Faculty of Pharmacia and Bionedicine, Mongolian National University of Medical Science, tel.: 976-991-142-53,
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Review
For citations:
Odonchimeg P., Ichinnorov D., Sarantuyaa Zh., Tumur-Ochir Ts., Choyzhamts G. Efficacy of different regimens of steroid therapy in patients with exacerbation of chronic obstructive pulmonary disease. PULMONOLOGIYA. 2015;25(1):58-63. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-1-58-63
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