Regulation of immune response in patients with COPD + asthma phenotype
https://doi.org/10.18093/0869-0189-2014-0-6-5-10
Abstract
The aim of this study was investigation of cellular and humoral immunity and of systemic inflammation in patients with COPD + asthma phenotype. Methods. The study involved 115 patients (60 males) including 44 patients with stable COPD stage I–II, 39 patients with mild controlled or partially controlled asthma and 12 patients with COPD + asthma phenotype. Twenty healthy nonsmokers were included as controls. Results. Immune disorders in patients with COPD + asthma phenotype included increased numbers of T-helpers, cytotoxic T-lymphocytes and B-lymphocytes and increased IgE level. Increased serum concentrations of TNF-α and IL-4 and decreased IFN-γ concentration were also found in these patients. Conclusion. Th2-type of the immune response was observed in patients with COPD + asthma phenotype; these findings could underlie persistent inflammation.
About the Authors
E. G. Lobanova
Vladivostok branch of Federal Institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation: 73G, Russkaya ul.; Vladivostok, 690105, Russia
Russian Federation
Russian Federation
PhD, Researcher of Laboratory of Biomedical Investigations, Vladivostok branch of Federal State Budget institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation; tel.: (423) 2-788-201
E. P. Kalinina
Vladivostok branch of Federal Institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation: 73G, Russkaya ul.; Vladivostok, 690105, Russia
Russian Federation
Russian Federation
MD, Senior Researcher of Rehabilitation Laboratory, Vladivostok branch of Federal State Budget institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation; tel.: (423) 2-788-201
V. V. Knyshova
Vladivostok branch of Federal Institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation: 73G, Russkaya ul.; Vladivostok, 690105, Russia
Russian Federation
Russian Federation
PhD, Senior Researcher of Rehabilitation Laboratory, Vladivostok branch of Federal State Budget institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation; tel.: (423) 2-788-201
M. V. Antonyuk
Vladivostok branch of Federal Institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation: 73G, Russkaya ul.; Vladivostok, 690105, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Rehabilitation Laboratory, Vladivostok branch of Federal State Budget institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation; tel.: (423) 2-788-201
B. I. Gel'tser
Federal Institution"VladivostokStateUniversityofEconomicsandService":41,Gogolyaul.,Vladivostok,690014,Russia
Russian Federation
Russian Federation
MD, Professor, Rector Adviser, Chief of Scientific and Educational Clinical Center, Federal State Budget Educational Institution "Vladivostok State University of Economics and Service"; tel.: (423) 240-42-28
Yu. K. Denisenko
Vladivostok branch of Federal Institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation: 73G, Russkaya ul.; Vladivostok, 690105, Russia
Russian Federation
Russian Federation
MD in Biology, Head of Laboratory of Biomedical Investigations, Vladivostok branch of Federal State Budget institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation; tel.: (423) 2-788-201
T. A. Gvozdenko
Vladivostok branch of Federal Institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation: 73G, Russkaya ul.; Vladivostok, 690105, Russia
Russian Federation
Russian Federation
MD, Director of Vladivostok branch of Federal State Budget institution "Far Eastern Scientific Center of Physiology and Respiratory Pathology", Northern Department of Russian Academy of Medical Science; Scientific Research Institute of Medical Climatology and Rehabilitation; tel.: (423) 2-788-201
References
1. Kalinina E.P., Lobanova E.G. Cytokine profile in patients with chronic obstructive pulmonary disease. Meditsinskaya immunologiya. 2012; 14 (6): 501–506 (in Russian). ?
2. Dugapova I.D., Anaev E.Kh., Chuchalin A.G. About a role of cytokines in bronchial asthma. Pul'monologiya. 2010; 4: 96–102 (in Russian). ?
3. Antonovich Zh.V., Tsarev V.P., Goncharova N.V. Natural regulatory T-cells and cytokines in patients with bronchial asthma in different periods of the disease. Immunopatologiya, allergologiya, infektologiya. 2012; 4: 35–44 (in Russian). ?
4. Kirillova N.A., Deev I.A., Kremer E.E. et al. Regulatory Tcell subpopulations in bronchial asthma and heterogeneous phenotypes of chronic obstructive pulmonary disease. Byulleten' sibirskoy meditsiny. 2011; 1: 48–54 (in Russian). ?
5. Kalinina E.P., Lobanova E.G. Diagnostic criteria of COPD progression. Byulleten' SO RAMN. 2010; 1 (141): 5–8 (in Russian). ?
6. Barnes P.J. Mechanisms in COPD: Differences from asthma. Chest. 2000; 117: 10–14.
7. Global Strategy for Diagnosis, Management, and Prevention of COPD. Updated 2011. Translated from English. Belevskiy A.S., ed. Moscow: Rossiyskoe respiratornoe obshchestvo; 2012 (in Russian).
Review
For citations:
Lobanova E.G., Kalinina E.P., Knyshova V.V., Antonyuk M.V., Gel'tser B.I., Denisenko Yu.K., Gvozdenko T.A. Regulation of immune response in patients with COPD + asthma phenotype. PULMONOLOGIYA. 2014;(6):5-10. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-6-5-10
Views:
1232
Email this article 