Респираторные вирусы и бактерии, антитела и цитокины у больных с фенотипом "бронхиальная астма и хроническая обструктивная болезнь легких"

Целью работы явился анализ респираторных вирусов и цитокинов в индуцированной мокроте больных с фенотипом "бронхиальная астма (БА) и хроническая обструктивная болезнь легких (ХОБЛ)" вне обострения и антигенов Mycoplasma pneumoniae и антител к микоплазмам и хламидиям в сыворотке крови. В образцах индуцированной мокроты у пациентов с фенотипом "БА + ХОБЛ" выявлены респираторные вирусы (риновирусы группы А, респираторносинцитиальный вирус и аденовирус), в крови – антигены микоплазм и / или антитела к M. pneumoniae и Chlamydia pneumoniae. Респираторные инфекции были ассоциированы с дисбалансом интерферонов (IFN) 1–3го типов и противовирусного белка МхА. При отсутствии экспрессии гена IFNβ в 58,3 % образцов детектировались РНК IFNα и в 42,9 % – РНК IFNλ. Показан дефицит функциональной активности IFNα и γ.

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