A significance of some prognostic immunomorphologic factors in adenocarcinoma of the lung
https://doi.org/10.18093/0869-0189-2014-0-5-27-31
Abstract
The aim of this study was to search tumor expression of thymidylate synthetase and some other immunomorphological markers and to determine their prognostic role for pulmonary adenocarcinoma.
Methods. Histological and immunohistochemical study of pulmonary adenocarcinoma has been conducted using several markers such as thymidylate synthetase, Ki67, p53, Bcl2, Bax.
Results. Thymidylate synthetase and cellular prolif eration activity marker Ki67 were revealed in 100 % of cases; p53, Bcl2 and Bax were revealed in 48 %, 7.9 % and 6.3 %, respectively. The results demonstrated a tendency to decrease 3year eventfree survival by 14 % (p = 0.1007) in patients with high thymidylate synthetase expression in comparison to patients with low expression.
Conclusion. Thymidylate synthetase could be used as a prognostic factor of pulmonary adenocarcinoma course.
About the Authors
S. A. Zin'kovich
Federal State Institution "Rostov Scientific and Research Oncological Institute", Healthcare Ministry of Russia; Rostov-na-Donu, Russia
Russian Federation
Russian Federation
E. M. Nepomnyashchaya
Federal State Institution "Rostov Scientific and Research Oncological Institute", Healthcare Ministry of Russia; Rostov-na-Donu, Russia
Russian Federation
Russian Federation
S. P. Pyl'tsin
Federal State Institution "Rostov Scientific and Research Oncological Institute", Healthcare Ministry of Russia; Rostov-na-Donu, Russia
Russian Federation
Russian Federation
T. O. Lapteva
Federal State Institution "Rostov Scientific and Research Oncological Institute", Healthcare Ministry of Russia; Rostov-na-Donu, Russia
Russian Federation
Russian Federation
Yu. N. Lazutin
Federal State Institution "Rostov Scientific and Research Oncological Institute", Healthcare Ministry of Russia; Rostov-na-Donu, Russia
Russian Federation
Russian Federation
O. V. Tarnopol'skaya
Federal State Institution "Rostov Scientific and Research Oncological Institute", Healthcare Ministry of Russia; Rostov-na-Donu, Russia
Russian Federation
Russian Federation
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Review
For citations:
Zin'kovich S.A., Nepomnyashchaya E.M., Pyl'tsin S.P., Lapteva T.O., Lazutin Yu.N., Tarnopol'skaya O.V. A significance of some prognostic immunomorphologic factors in adenocarcinoma of the lung. PULMONOLOGIYA. 2014;(5):27-31. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-5-27-31
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