Clinical and pathogenic aspects of arterial stiffness and the left heart remodeling in patients with chronic obstructive pulmonary disease and coronary artery disease
https://doi.org/10.18093/0869-0189-2014-0-5-5-10
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Full Text:
Abstract
Aim. The aim of this study was to evaluate a relationship between clinical and functional parameters, arterial stiffness and the left heart remodeling in patients with COPD and comorbid coronary artery disease (CAD).
Methods. Fifty COPD patients with or without comorbid CAD were includ ed. This was a prospective observational 52week study. Lung function was testing, noninvasive arteriography, echocardiography were used. Oxygen saturation and cytokine (IL6, IL8, TNFα) were measured.
Results. Severe and very severe COPD and CAD have common risk factors, such as smoking, hypoxemia, systemic inflammation, which can cause vascular wall remodeling. Increased arterial stiffness affects hemodynamics and impedes myocardial relaxation that in turn leads to diastolic dysfunction and reduced left heart contractility Direct relationships between systemic inflammation biomarkers, arterial stiffness, systolic and diastolic dysfunction were found in patients with severe and very severe COPD independ ently on comorbid CAD.
About the Authors
M. G. MamaevaRussian Federation
E. A. Sobko
Russian Federation
A. Yu. Kraposhina
Russian Federation
I. A. Solov'eva
Russian Federation
Competing Interests:
ассистент кафедры внутренних болезней № 2 с курсом ПО ГБОУ ВПО "КрасГМУ им. проф. В.Ф.Войно Ясенецкого" Минздрава России; тел.: (391) 2283469
N. S. Logacheva
Russian Federation
N. S. Eydemiller
Russian Federation
T. N. Kuz'minova
Russian Federation
A. B. Salmina
Russian Federation
I. V. Demko
Russian Federation
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Review
For citations:
Mamaeva M.G., Sobko E.A., Kraposhina A.Yu., Solov'eva I.A., Logacheva N.S., Eydemiller N.S., Kuz'minova T.N., Salmina A.B., Demko I.V. Clinical and pathogenic aspects of arterial stiffness and the left heart remodeling in patients with chronic obstructive pulmonary disease and coronary artery disease. PULMONOLOGIYA. 2014;(5):5-10. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-5-5-10
ISSN 2541-9617 (Online)