Clinical efficacy of andriol in patients with bronchial asthma and acquired androgen deficiency
https://doi.org/10.18093/0869-0189-2011-0-6-99-102
Abstract
Summary. The aim of this study was to investigate influence of andriol replacement therapy on clinical course of asthma in patients with acquired androgen deficiency. Thirty six males in age of 53.5 ± 2.4 years with asthma history of 1 to 8 years were examined and treated. Besides of lung function and androgen status, quality of life was assessed before and after andriol replacement therapy. Results of the study showed favorable influence of the andriol replacement therapy on severity and frequency of asthma attacks as well as improvement in several parameters of the patients' quality of life.
About the Authors
V. M. Provotorov
Воронежская государственная медицинская академия им. Н.Н. Бурденко
Russian Federation
Russian Federation
M. A. Nikitin
Воронежская государственная медицинская академия им. Н.Н. Бурденко
Russian Federation
Russian Federation
References
1. Печерский А.В. Частичный возрастной андрогенный дефицит. Влияние на развитие метаболического синдрома и патологии предстательной железы. СПб.: СПб МАПО; 2005.
2. Hamano N., Terada N., Maesako K. at al. Effect of sex hormones on eosinophilie inflammation in nasal mucosa. Allergy Asthma Proc. 1998; 19 (5): 263–269.
3. Shaheen S.O., Hines M., Newson R.B. at al. Maternal testosterone in pregnancy and atopic outcomes in childhood. Allergy 2007; 62 (1): 25–32.
4. Hayashi T., Adachi Y., Hasegawa K. at al. Less sensitivity for late airway inflammation in males than females in BALB/c mice. Scand. J. Immunol. 2003; 57 (6): 562–567.
5. Osman M. Therapeutic implications of sex differences in asthma and atopy. Arch. Dis. Child. 2003; 88 (7): 587–590.
6. Chen W., Mempel M., Schober W. at al. Gender difference, sex hormones, and immediate type hypersensitivity reactions. Allergy 2008; 63 (11): 1418–1427.
7. Leposavic' G., Perisié, M., Kosec D. at al. Neonatal testosterone imprinting affects thymys development and leads to phenotypic rejuvenation and masculinization of the peripheral blood T – cell compartment in adult female rats. Brain Behav. Immun. 2009; 23 (2): 294–304.
8. Дедов И.И., Калиниченко С.Д. Возрастной андрогенный дефицит у мужчин. М.: Практическая медицина; 2006.
Review
For citations:
Provotorov V.M., Nikitin M.A. Clinical efficacy of andriol in patients with bronchial asthma and acquired androgen deficiency. PULMONOLOGIYA. 2011;(6):99-102. (In Russ.) https://doi.org/10.18093/0869-0189-2011-0-6-99-102
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