Forecast of the socioeconomic burden of COPD in the Russian Federation in 2022










https://doi.org/10.18093/0869-0189-2022-32-4-507-516
- Р Р‡.МессенРТвЂВВВВВВВВжер
- РћРТвЂВВВВВВВВнокласснРСвЂВВВВВВВВРєРСвЂВВВВВВВВ
- LiveJournal
- Telegram
- ВКонтакте
- РЎРєРѕРїРСвЂВВВВВВВВровать ссылку
Full Text:
Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by a high level of morbidity and mortality and is associated with significant social and economic losses for the health care system and society.
Aim. To predict the socio-economic burden of COPD in the Russian Federation in 2022, including the cost of drug treatment.
Methods. The socio-economic burden of COPD in the Russian Federation in 2022 was predicted with and without taking into account the impact of COVID-19. The analysis of the cost of illness included the calculation of direct and indirect costs due to COPD. Data of Federal State Statistics Service, the State Guarantee Program of Free Medical Care for Citizens of Russian Federation, and data from the regional register of drug treatment of patients with COPD were used. Costs of medical care (ambulatory, hospital, and emergency care) were calculated based on compulsory health insurance tariffs. The disability benefits payments were calculated based on number of disabled persons and the amount of the disability benefit in each group. Indirect costs (or economic losses) included losses from products which were not produced due to disability and premature mortality of working-aged adults.
Results. The predicted total economic losses due to COPD in 2022 will be 428.5 billion rubles when taking into account the impact of COVID-19, and 378.9 billion rubles when not accounting for COVID-19. Losses in the economy due to decreased labor productivity because of premature deaths (86%) are major part of the main burden. The cost of drug therapy for patients with COPD in outpatient settings will amount to over 17 billion rubles.
Conclusion. Potential economic burden of COPD in 2022 depends on the incidence of COVID-19 and could be 0.34% of the GDP. Priority should be given to measures aimed at preventing the occurrence of COPD by correcting risk factors in the population, early diagnosis, slowing the progression of the disease and preventing exacerbations. Prevention of respiratory infections including COVID-19 in patients with COPD plays a special role.
Keywords
About the Authors
O. M. DrapkinaRussian Federation
Oxana M. Drapkina, Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Director
Petroverigsky per., 10, building 3, Moscow, 101990
tel.: (495) 624-11-46
Competing Interests:
The authors declared no conflict of interest.
A. V. Kontsevaya
Russian Federation
Anna V. Kontsevaya, Doctor of Medicine, Deputy director on science and analytics
Petroverigsky per., 10, building 3, Moscow, 101990
tel.: (495) 223-49-58
Competing Interests:
The authors declared no conflict of interest.
D. K. Mukaneeva
Russian Federation
Dinara K. Mukaneeva, Researcher, Public Health Promotion Department
Petroverigsky per., 10, building 3, Moscow, 101990
tel.: (499) 553-68-66
Competing Interests:
The authors declared no conflict of interest.
M. I. Smirnova
Russian Federation
Marina I. Smirnova, Candidate of Medicine, Head of Laboratory for Prevention of Chronic Respiratory Diseases
Petroverigsky per., 10, building 3, Moscow, 101990
tel.: (499) 553-69-32
Competing Interests:
The authors declared no conflict of interest.
A. A. Antsiferova
Russian Federation
Alexandra A. Antsiferova, Junior Researcher, Public Health Promotion Department
tel.: (499) 553-68-66
Petroverigsky per., 10, building 3, Moscow, 101990
Competing Interests:
The authors declared no conflict of interest.
M. M. Lukyanov
Russian Federation
Mikhail M. Lukyanov, Candidate of Medicine, Head of the Department of Clinical Cardiology
Petroverigsky per., 10, building 3, Moscow, 101990
tel. (499) 553-67-35
Competing Interests:
The authors declared no conflict of interest.
A. O. Myrzamatova
Russian Federation
Azaliia O. Myrzamatova, Candidate of Medicine, Researcher, Public Health Promotion Department
Petroverigsky per., 10, building 3, Moscow, 101990
tel.: (499) 553-68-66
Competing Interests:
The authors declared no conflict of interest.
G. I. Mokhovikov
Russian Federation
Gennady I. Mokhovikov, Candidate of Medicine, Head of pulmonology department
ul. Pirogova 3, Petrozavodsk, Republic of Karelia, 185019
tel.: (900) 463-86-10
Competing Interests:
The authors declared no conflict of interest.
M. B. Khudyakov
Russian Federation
Mikhail B. Khudyakov, Lead Engineer, Public Health Promotion Department
Petroverigsky per., 10, building 3, Moscow, 101990
tel.: (499) 553-68-66
Competing Interests:
The authors declared no conflict of interest.
S. N. Avdeev
Russian Federation
Sergey N. Avdeev, Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Head of the Department of Pulmonology, N. V. Sklifosovsky Institute of Clinical Medicine
SPIN-code: 1645-5524
ul. Trubetskaya 8, build. 2, Moscow, 119991
tel.: (495) 708-35-76
Competing Interests:
The authors declared no conflict of interest.
References
1. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. 2021 Report. Available at: https://goldcopd.org/wp-content/uploads/2020/11/GOLD-REPORT-2021-v1.1-25Nov20_WMV.pdf
2. Vanfleteren L.E., Franssen F.M., Wesseling G., Wouters E.F. The prevalence of chronic obstructive pulmonary disease in Maastricht, the Netherlands. Respir. Med. 2012; 106 (6): 871-874. https://doi.org/10.1016/j.rmed.2012.01.008.
3. Watz H., Pitta F., Rochester C.L. et al. An official European Respiratory Society statement on physical activity in COPD. Eur. Respir. J. 2014; 44 (6): 1521-1537. https://doi.org/10.1183/09031936.00046814.
4. Aisanov Z., Avdeev S., Arkhipov V. et al. Russian guidelines for the management of COPD: algorithm of pharmacologic treatment. Int. J. Chron. Obstruct. Pulmon. Dis. 2018; 13: 183-187. https://doi.org/10.2147/COPD.S153770.
5. Andreeva E., Pokhaznikova M., Lebedev A. et al. The prevalence of chronic obstructive pulmonary disease by the Global Lung Initiative equations in North-Western Russia. Respiration. 2016; 91 (1): 43-55. https://doi.org/10.1159/000442887.
6. Landis S.H., Muellerova H., Mannino D.M. et al. Continuing to confront COPD International Patient Survey: methods, COPD prevalence, and disease burden in 2012 - 2013. Int. J. Chron. Obstruct. Pulmon. Dis. 2014; 9 (1): 597-611. https://doi.org/10.2147/COPD.S61854.
7. Arkhipov V.V., Arkhipova D.E., Stukalina E.Yu., Lazarev A.A. [Copd phenotypes in Russia: characteristics and treatment]. Prakticheskaya pul'monologiya. 2016; (3): 20-25. Available at: https://cyberleninka.ru/article/n/chastota-vstrechaemosti-otdelnyh-fenotipov-hronicheskoy-obstruktivnoy-bolezni-legkih-v-rossiyskoy-federatsii-ih-harakteristiki-i (in Russian).
8. Ovsyannikov E.S., Avdeev S.N., Budnevskiy A.V. et al. [COVID-19 and chronic obstructive pulmonary disease: what is known about the unknown]. Tuberkulez i bolezni legkikh. 2021; 99 (2): 6-15. https://doi.org/10.21292/2075-1230-2021-99-2-6-15 (in Russian).
9. Kontsevaya A.V., Mukaneeva D.K., Balanova Yu.A. et al. [Economic burden of respiratory diseases and chronic obstructive pulmonary disease in Russian Federation, 2016]. Pul'monologiya. 2019; 29 (2): 159-166. https://doi.org/10.18093/0869-0189-2019-29-2-159-166 (in Russian).
10. Kontsevaya A.V., Myrzamatova A.O., Mukaneeva D.K. et al. [The economic burden of main non-communicable diseases in the Russian Federation in 2016]. Profilakticheskaya meditsina. 2019; 22 (6): 1: 18-23. https://doi.org/10.17116/profmed20192206118 (in Russian).
11. Decree of the Government of the Russian Federation of December 28, 2021 No.2505 [“On the Program of State Guarantees of Free Medical Assistance to Citizens for 2022 and for the Planning Period of 2023 and 2024”]. Available at: http://static.government.ru/media/files/de3NXxmFdnBk5LLok0KHjVaKd7aw67Ul.pdf (in Russian).
12. European Respiratory Society. European Lung White Book. Huddersfield: European Respiratory Society Journal, Ltd; 2003. Dostupno na: https://www.ers-education.org/publications/european-lung-white-book
13. Pronina E.Yu. [Top of the iceberg - epidemiology of COPD (literature review)]. Vestnik sovremennoy klinicheskoy meditsiny. 2011; 4 (3): 18-23. Available at: https://cyberleninka.ru/article/v/vershina-aysberga-epidemiologiya-hobl-obzor-literatury (in Russian).
14. Gutiérrez Villegas C., Paz-Zulueta M., Herrero-Montes M. et al. Cost analysis of chronic obstructive pulmonary disease (COPD): a systematic review. Health Econ. Rev. 2021; 11 (1): 31. https://doi.org/10.1186/s13561-021-00329-9.
15. Rehman A.U., Hassali M.A.A., Muhammad S.A. et al. The economic burden of chronic obstructive pulmonary disease (COPD) in Europe: results from a systematic review of the literature. Eur. J. Health Econ. 2020; 21 (2): 181-194. https://doi.org/10.1007/s10198-019-01119-1.
16. Woo L., Smith H.E., Sullivan S.D. The economic burden of chronic obstructive pulmonary disease in the Asia-Pacific region: a systematic review. Value Health Reg. Issues. 2019; 18: 121-131. https://doi.org/10.1016/j.vhri.2019.02.002.
17. Bednarek M., Maciejewski J., Wozniak M. et al. Prevalence, severity and underdiagnosis of COPD in the primary care setting. Thorax. 2008; 63 (5): 402-407. https://doi.org/10.1136/thx.2007.085456.
18. Arkhipov V., Arkhipova D., Miravitlles M. et al. Characteristics of COPD patients according to GOLD classification and clinical phenotypes in the Russian Federation: the SUPPORT trial. Int. J. Chron. Obstruct. Pulmon. Dis. 2017; 12: 3255-3262. https://doi.org/10.2147/COPD.S142997.
19. Martinez F.J., Rabe K.F., Ferguson G.T. et al. Reduced all-cause mortality in the ETHOS trial of budesonide/glycopyrrolate/formoterol for chronic obstructive pulmonary disease. A randomized, double-blind, multicenter, parallel-group study. Am. J. Respir. Crit. Care Med. 2021; 203 (5): 553-564. https://doi.org/10.1164/rccm.202006-2618OC.
20. Lipson D.A., Crim C., Criner G.J. et al. Reduction in all-cause mortality with fluticasone furoate/umeclidinium/vilanterol in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2020; 201 (12): 1508-1516. https://doi.org/10.1164/rccm.201911-2207OC.
21. Salem A., Zhong H., Ramos M. et al. Potential clinical and economic impact of optimised maintenance therapy on discharged patients with COPD after hospitalisation for an exacerbation in China. BMJ Open. 2021; 11 (4): e043664. https://doi.org/10.1136/bmjopen-2020-043664.
22. Bagisheva N.V. [Issues of epidemiology and pharmacoeconomics of chronic obstructive lung disease in large industrial centre in the south of western Siberia]. Vestnik sovremennoy klinicheskoy meditsiny. 2009; 2 (2): 12-15. Available at: http://vskmjournal.org/images/Files/Issues_Archive/2009/Issue_2/VSKM_2009_N_2_p12-15.pdf (in Russian).
23.
Review
For citations:
Drapkina O.M., Kontsevaya A.V., Mukaneeva D.K., Smirnova M.I., Antsiferova A.A., Lukyanov M.M., Myrzamatova A.O., Mokhovikov G.I., Khudyakov M.B., Avdeev S.N. Forecast of the socioeconomic burden of COPD in the Russian Federation in 2022. PULMONOLOGIYA. 2022;32(4):507-516. (In Russ.) https://doi.org/10.18093/0869-0189-2022-32-4-507-516
ISSN 2541-9617 (Online)