БЕЗОПАСНОСТЬ ИНГАЛЯЦИОННЫХ ГЛЮКОКОРТИКОСТЕРОИДОВ В ТЕРАПИИ БРОНХИАЛЬНОЙ АСТМЫ


https://doi.org/10.18093/0869-0189-2014-0-3-113-120

Полный текст:


Аннотация

Основными препаратами, с помощью которых обеспечивается длительный контроль над бронхиальной астмой (БА), являются ингаляционные глюкокортикостероиды (иГКС), обладающие выраженным противовоспалительным эффектом. При воздействии иГКС снижается уровень смертности при БА, улучшается функция легких, облегчаются симптомы, уменьшается число обострений и повышается качество жизни пациентов. Молекулы иГКС могут различаться по своему терапевтическому индексу, но в эквипотентных дозах они одинаково эффективны. Максимальный эффект иГКС проявляется уже при применении низких / средних доз, предпочтительных для длительного лечения БА. При корректном использовании в диапазоне низких / средних доз иГКС проявляется мало нежелательных эффектов (НЭ), однако риск их возникновения увеличивается с повышением доз.
Данная статья посвящена фармакокинетическим свойствам и механизму действия иГКС, возможным локальным и системным НЭ и мерам их профилактики.

Об авторе

Н. М. Ненашева
ГБОУ ДПО "Российская медицинская академия последипломного образования" Минздрава России: 123995, Москва, ул. Баррикадная, 2 / 1
Россия

д. м. н., профессор кафедры клинической аллергологии ГБОУ ДПО РМАПО; тел.: (499) 196-19-54



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Дополнительные файлы

Для цитирования: Ненашева Н.М. БЕЗОПАСНОСТЬ ИНГАЛЯЦИОННЫХ ГЛЮКОКОРТИКОСТЕРОИДОВ В ТЕРАПИИ БРОНХИАЛЬНОЙ АСТМЫ.  Пульмонология. 2014;(3):113-120. https://doi.org/10.18093/0869-0189-2014-0-3-113-120

For citation: Nenasheva N.M. SAFETY OF INHALED CORTICOSTEROIDS IN THE THERAPY OF BRONCHIAL ASTHMA. Russian Pulmonology. 2014;(3):113-120. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-3-113-120

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