Night pharmacokinetics of single dosage theophylline: comparison of three drugs in similar conditions
Abstract
We have carried out a stead y state pharmacokynetic comparison of three different theophylline preparations in nine healthy volunteers using a once a day dosage schedule of 600 mg theophylline given before bedtime for four days. The preparations tested were Retafyllin 200 mg depot tablet (R), Theo-Dur 200 mg depot tablet (T) and Uniphyllin 200 mg tablet (U). All preparations in steady state reached the serum level of 8.9— 10.2 microg/ml after a single evening dose of theophylline 600 mg. The pharmacokinetic profile of these slow release theophylline preparations was such that there is no risk of exceeding the therapeutic range even after a rather high evening dose. Individual variation was also observed in the present study but nobody exceeded the therapeutic range. The pharmacokinetic profiles of R and U were quite similar and they seemed to have suitable pharmacokinetic properties for once a day dosage, and they showed a more sustained action than T. Only minimal gastrointestinal side effects were reported during this study.
About the Authors
P. Karttunen
А/О «Орион Фармацевтика»; Университет Куопио
Finland
Finland
H. Tukiainen
А/О «Орион Фармацевтика»; Университет Куопио
Finland
Finland
S. Nykanen
А/О «Орион Фармацевтика»; Университет Куопио
Finland
Finland
V. Saano
А/О «Орион Фармацевтика»; Университет Куопио
Finland
Finland
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Review
For citations:
Karttunen P., Tukiainen H., Nykanen S., Saano V. Night pharmacokinetics of single dosage theophylline: comparison of three drugs in similar conditions. PULMONOLOGIYA. 1991;(3):28-32. (In Russ.) https://doi.org/617.234.015
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