A relationship between lung function and arterial wall stiffness in patients with bronchial asthma
https://doi.org/10.18093/0869-0189-2011-0-5-61-64
Abstract
Summary. The purpose of the study was to investigate relationship between parameters of lung function and arterial stiffness in patients with bronchial asthma during the follow-up at a pulmonary and allergological center of Krasnoyarsk. This was a prospective open study. Lung function was assessed using spirometry and body plethysmography at admission and in 48 weeks, arterial stiffness was evaluated with indirect arteriography at the same time points. Statistically significant positive relationship was found between expiratory bronchial resistance and main parameters of arterial stiffness (pulse wave velocity in the aorta and augmentation index) and also between the ratio of expiratory and inspiratory bronchial resistances and augmentation index. Oxygen saturation inversely related to pulse wave velocity in the aorta; this fact, in our opinion, indicates an influence of hypoxia and bronchial obstruction caused by chronic persistent airway inflammation on increased stiffness of proximal arteries.
About the Authors
E. A. Sobko
ГОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого" Росздрава
Russian Federation
Russian Federation
A. Yu. Kraposhina
ГОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого" Росздрава
Russian Federation
Russian Federation
I. V. Demko
ГОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого" Росздрава
Russian Federation
Russian Federation
N. G. Ryazanova
ГОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого" Росздрава
Russian Federation
Russian Federation
O. P. Ishchenko
ГОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого" Росздрава
Russian Federation
Russian Federation
L. I. Kaptyuk
ГОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого" Росздрава
Russian Federation
Russian Federation
A. B. Salmina
ГОУ ВПО "Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого" Росздрава; НИИ молекулярной медицины и патобиохимии
Russian Federation
Russian Federation
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Review
For citations:
Sobko E.A., Kraposhina A.Yu., Demko I.V., Ryazanova N.G., Ishchenko O.P., Kaptyuk L.I., Salmina A.B. A relationship between lung function and arterial wall stiffness in patients with bronchial asthma. PULMONOLOGIYA. 2011;(5):61-64. (In Russ.) https://doi.org/10.18093/0869-0189-2011-0-5-61-64
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