The role of supperession of phagocyting leucocytes of the airways in the patnogenesis of chronic bronchitis
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Abstract
The functional activity of phagocyting cells isolated from bronchoalveolar lavage (BAL) of patients having chronic bronchitis (CB) was studied by HC — test using a monolayer of washed cells in the presence of autologic plasma, cell — deprived BAL and phagocytes stimulator.
Significant suppression of the functional activity of the BAL cells in patients with CB in comparison to control group was found. Tests done on the periferal blood leucocytes of the healthy donors demonstrated that the inhibitory effect is due to the absence of the non — cellclar BAL of the CB patients and does not disappear upon heating of BAL. The suppression of the reducing activity was observed in the presence of washed BAL cells in the patients with parkedly reduced functional activity and the suprapellet fluid obtained during culturing of the cells. The inhibitory effect was directly proportional to the marked atrophic changes of the bronchial mucosa.
About the Authors
V. B. Beilyna
ММСИ им. Н.А. Семашко
Russian Federation
Russian Federation
V. I. Shevelyov
ММСИ им. Н.А. Семашко
Russian Federation
Russian Federation
V. V. Androsov
ММСИ им. Н.А. Семашко
Russian Federation
Russian Federation
A. I. Veshkina
ММСИ им. Н.А. Семашко
Russian Federation
Russian Federation
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Review
For citations:
Beilyna V.B., Shevelyov V.I., Androsov V.V., Veshkina A.I. The role of supperession of phagocyting leucocytes of the airways in the patnogenesis of chronic bronchitis. PULMONOLOGIYA. 1992;(1):49-52. (In Russ.)
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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)
ISSN 2541-9617 (Online)
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