Patterns of expression of type 8 and 17 keratins in different histhological entities of lung cancer
Abstract
Expression of type 8 and 17 keratins was assessed immuno-morphologically using commercial kits produced in the Cardiology Centre. The study was done using cryostated slices of the tumors obtained from patients operated on in the Gertzen’s Oncological Institute. Heterogeneicity of the cell contents of squamous cell lung cancer was found. In the morphogenesis of the squamous cell lung carcinoma, despite its differentiation stage, cells with mucinoud and epidermoid differentiation patterns take part. In some adenocarcinomas and small-cell lung carcinomas, besides cell elements, containing mucinoid (8) type of keratin, cells expressing epidermoid (17) type of keratin were also present. The study prompted to conclude that 8 and 17 types of keratins can be used as marker proteins demonstrating mucinoid or epithelial trends of differentiation of the cell elements in different histological entities of lung cancer.
About the Authors
G. A. Frank
Московский научно-исследовательский онкологический институт им. П.А. Герцена
Russian Federation
Russian Federation
L. V. Litvinova
Московский научно-исследовательский онкологический институт им. П.А. Герцена
Russian Federation
Russian Federation
N. V. Vyaltseva
Московский научно-исследовательский онкологический институт им. П.А. Герцена
Russian Federation
Russian Federation
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Review
For citations:
Frank G.A., Litvinova L.V., Vyaltseva N.V. Patterns of expression of type 8 and 17 keratins in different histhological entities of lung cancer. PULMONOLOGIYA. 1992;(1):27-31. (In Russ.)
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