Impaired glucocorticoid homeostasis and its impact on bronchial sensitivity and reactivity at different stages of bronchial asthma
Abstract
The study has revealed increased bronchial reactivity to acetylcholine in 2/3 of direct relatives of asthmatic patients, in 3/4 of patients with PA and in all BA patients. It was found that 11 OKS plasma levels tended to increase after acetylcholine challenge in direct relatives of BA patients, PA patients and normals, and significantly decreased in BA patients suggesting the inadequacy of their adrenal cortex response to acetylcholine challenge. Inverse correlation was found between glucocorticoid plasma levels and bronchial hyperreactivity. Evidently, glucocorticoid insufficiency plays an important part in bronchial hyperreactivity.
About the Author
В. Trofimov
I Ленинградский медицинский институт им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Trofimov Impaired glucocorticoid homeostasis and its impact on bronchial sensitivity and reactivity at different stages of bronchial asthma. PULMONOLOGIYA. 1992;(1):17-20. (In Russ.)
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