The double-blind study of the phospholipidal liposome’s effectivity in treatment of bronchoobstructive syndrome

Abstract

The study of the liposomal remedy for inhalational application named as Lipin was earned out in two groups of patients with various forms of bronchoobstructive diseases (bronchial asthma, chronic obstructive bronchitis). The remedy was diluted ex tempore with saline and was dispersed by the ultrasound inhalator. 9 patients comparable in sex, age, the disease duration, with the general group of the patients were inhalated with saline and were as a control. To estimate the influence of the liposomal remedy on the hyperreactivity of the bronchial tree the supplemental study in 12 patients aged 18 years with bronchial asthma (BA) in the remission was earned out. The hyperreactivity syndrome was diagnosed on results of bronchial challenge with metacholine. The obtained results allow to testify about the greatest efficacy of the remedy in the group of patients with BA and in cases when the bronchial conductivity disturbance is formed by obstruction on distal and intermediate levels of bronchi especially. Most nonsatisfactory results were obtained in patients with obstructive bronchitis. The preliminary inhalation with phospholipidal liposomes, as well as the 6 day course medication, allows to diminish essentially the metacholinic reactivity of the airway.