Influence of plasm apheresis on pulmonary microcirculation in patients with fibrosing alveolitis

Abstract

Pulmonary microcirculation features in patients with exogenous allergic alveolitis (EAA) during various phases of the disease and under various therapeutic programs were studied. The microcirculation was estimated with radionuclear drug Tc99. Moreover, the aggregation ability of erythrocytes was studied. Considerable disorders of microcirculation progressing in the interstitial pulmonary tissue during active inflammation were revealed in patients with EAA. The braking action of treatment programs using plasm apheresis on microcirculation disorders was found. The com m on basis pharmacotherapy of EAA was not capable to brake the microcirculation disorders progressing estimated with radionuclear methods independently from clinical results of treatment. Aggregation ability disorders of erythrocytes were well corrected with basis pharmacotherapy and with plasmapheresis.