Immunological and biochemical characteristics of pathogenesis of cryptogenic fibrosing alveolitis and sarcoidosis
Abstract
Immunological and biochemical parameters such as: Interleukin 1 and 2 (IL-1, IL-2), prostaglandin E and F2alfa levels, subpopulations of T-lymphocytes, the activity of elastase and collagenase were studied in patients with cryptogenic fibrosing alveolitis and pulmonary sarcoidosis.
It was found that the immunoreactivity of the patients is characterized by high levels of the IL-1 and IL-2 activity and the T-lymphocyte subpopulation disbalance. High levels of elastase and collagenase in bronchoalveolar fluid in these patients were detected.
About the Authors
T. P. Ses
Государственный научный центр пульмонологии М3 РФ
Russian Federation
Russian Federation
I. V. Pochodsey
Государственный научный центр пульмонологии М3 РФ
Russian Federation
Russian Federation
A. G. Bulychev
Государственный научный центр пульмонологии М3 РФ
Russian Federation
Russian Federation
E. A. Leonteva
Государственный научный центр пульмонологии М3 РФ
Russian Federation
Russian Federation
References
1. Campbell D. A., Poulter L. W., du Bois R. M. Phenotypic analysis of BAL cells from patients with interstitial Lung disease // Thorax.— 1986.— Vol. 41, N 6.— P. 429—434.
2. MUller-Quernheim J., Pfiefer S., Strausz J. et al. Correlation of clinical and Immunological parameters of the Inflammatory Activity of pulmonary Sarcodosis // Am. Rev. Respir. Dis.— 1991. — Vol. 144, N 6.— P. 1322—1329.
3. Ozaki T., Hayashi H., Tani K. et al. Neutrophil chemotactic Factors in the respiratory Tract of Patients with Chronic Airway Diseases of Idiopatic Pulmonary Fibrosis // Ibid.— 1992. — Vol. 145, N 1.— P. 85—91.
4. Pohl W. R., Thompson A. B., Korn H. Serum procollagen III Peptid level in subjects with San coidosis // Ibid.— N 2.— P. 413—417.
5. Thomas P. D., Hunninghake G. U/. Current concepts of the pathogenesis of sarcoidosis // Ibid.— 1987.— Vol. 135, N 3.— P. 747—760.
6. Turner-Warwich M., Haslam P. L. The value of serial bronchoalveolar lavages in assessing the clinical progress of patients with cryptogeneic fibrosing alveolities // Ibid.— N. i._ p. 26—34.
Review
For citations:
Ses T.P., Pochodsey I.V., Bulychev A.G., Leonteva E.A. Immunological and biochemical characteristics of pathogenesis of cryptogenic fibrosing alveolitis and sarcoidosis. PULMONOLOGIYA. 1993;(2):83-86. (In Russ.)
Views:
122
Email this article 