The profilactic action of Ditec airsoles on bronchial constriction caused by physical exertion
Abstract
In 7 patients with mixed genesis bronchial asthma which demontrated the FEV1 decrease more than 20 percents after finishing the test with the exercise on the bicycle, the profilactic effect of single inhalation and course treatment of Berotec. Ditec, and Bichromate was studied.
In 30 minutes and 2 hours after single inhalation of Berotec, Ditec, and Bichromate, the FEV1 increase was revealed in 23 and 21.6 %, in 26 and 23.5 %, and in 5.8 and 6.3 % respectively. The ergometry in 2 hours after two inhalations of Ditec caused the FEV1 decrease in 7.4 % on average in 10 minutes after cancelling the exercise. Bronchial constriction was not determined in all the 7 patients. After two inhalations of Berotec the FEV1 decrease in 8.9 % on average in 8—10 minutes of recovery was observed. 4 patients indicated subjectively favorable protective action of Berotec. The protective action at the background of two Bichromate inhalations on bronchial constriction was revealed in 6 patients. The ergometry being executed in 12 hours after the preparation dose evening administration revealed the FEV1 maximal decrease in 7.8 % in 8—10 minutes after finishing the exercise after the 4-weeks course treatment of Ditec, at the background of the Bichromate treatment — in 6.6 %; at the Berotec one — in 10.8 %.
About the Authors
A. N. TsoyRussian Federation
L. H. Gaurilenko
Russian Federation
E. V. Titova
Russian Federation
References
1. Boner A. L., Antonini Andreoli A., De-Stefano G., Sette L. Comparison of the effects of inhaled calcium antagonist verapamil, sodium cromoglycate and iprotropium bromide on exercise-induced bronchoconstriction in children with asthma // Eur. J. Pediatr.— 1987.— Vol. 146, N 4.— P. 408—411.
2. Boulet L. P., Turcotte H., Tennina S. Comparative efficacy of salbutamol, iprotropium and cromoglycate in the prevention of bronchospasm induced by exercise and hyperosmolar challenges // J. Allergy. Clin. Immunol.— 1989.—Vol. 83, N 5.—P. 882—887.
3. Bundgaard A. Exercise-induced asthma // Eur. J. Respir. Dis.— 1986.— suppl. 143.— P. 51—56.
4. Clarke P. S., Ratowsky D. A. Effects of fenoterol hydrobromide and sodium cromoglycate individually and in combination on postecercise asthma // Ann. Allergy.— 1990.— Vol. 64, N 2.—pt. 2.— P. 187—190.
5. Corrias A., Pelosi U., Corona G. B., Minelli R., Peri М., Corda R. Efficacy of brozaterol (vs salbutamol) in asthma induced by physical exercise in shildren // Pediatr. Med. Chir.— 1989.—Vol. 11, N 2.—P. 161 — 163.
6. Debelic М., Hertel G., Konig G. Double-blind crossover study comparing sodium cromoglycate, reptoterol, reptoterol plus sodium cromoglycate, and placebo in exerciseinduced asthma // Ann. Allergy.— 1988.— Vol. 61, N 1.— P. 25—29.
7. Hussein A., Forderer A., Abelitis М., Koch I. Effect of the diagnosis and prevention of exercise-induced bronchial obstruction on sports participation by asthmatic school children // Monatsschr. Kinderheikd.— 1988.— Bd. 136, N 12.— S. 819—823.
8. Johnson С. E., Belfield P. W., Davis S., Cooke N. J., Spencer A., Davies J. A. Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol // Thorax.— 1986.— Vol. 41, N 4.— P. 290—294.
9. Konig P., Hordrik N. L., Krentz C. The preventive effect and duration of action of nedocromil sodium and cromolyn sodium on exercise induced asthma (EIA) in adults // J. Allergy Clin. Immunol.— 1987.— Vol. 79, N 1.— P. 64—68.
10. Likura Y., Inui H., Obata Т., Nagakura Т., Sugimoto H., Lee Th., Kay A. B. Drug effects on exercise-induced late asthmatic responces // N. Engl. reg. Allergy Proc.— 1988.— Vol. 9, N 3.— P. 203—207.
11. Patel K. R., Tullett W. М., Neale M. G., Wall R. Т., Tan К. M. plasma concentrations of sodium cromoglycate given by nebulization and metered dose inhalers in patients with exerciseinduced asthma: relationship to protective effect // ’ Br. J. Clin. Pharmacol.— 1986.— Vol. 21, N 2.— P. 231—233.
12. Rohr A. S., Siegl S. C., Katz R. М., Rachelefsky G. S., Spector S. L., Lanier R. A comparison of inhaled alvuterol and cromolyn in the prophylaxis of exercise-induced bronchospasm // Ann. Allergy.— 1987.— Vol. 59, N 2.— P. 107—109.
13. Russo G. H., BeLia C. A., Bodas A. W. Exercise-induced Asthma (El A), its prevention with the combined use of iprotropium bromide and fenoterol // Respiration.— 1986.— Vol. 50, Suppl. 2.— P. 258—261.
14. Schmidt A., Bundgaard A. Exercise-induced asthma after inhalation of aerosols with different osmolarities // Eur. J. Respir. Dis.— 1986.— Suppl. 143.— P. 57—61.
15. Schmidt A., Diamant B, Bundgaard A., Madsen P. L. Ergogenic effect of inhaled beta-2-agonists in asthmatics // Int. J. Sports Med.— 1988.— Vol. 9, N 5.—P. 338—340.
16. Svennonius E, Arborelius M. Jr., Wiberg R., Ekberg P. Prevention of exercise-unduced asthma by drugs inhaled from metered aerosols // Allergy.— 1988.— Vol. 43, N 4.— P. 252—257.
17. Tan W. C., lim Т. К. Double-blind comparison of the protective effect of sodium cromoglycate and ketotifen on exercise-unduced asthma in adults.— 1987.— Vol. 42, N 4.— P. 315—317.
18. Weiner P., Saaid М., Reshef A. Isotonic nebulized disodium cromoglycate provides better protection against methacholineand exercise-unduced bronchoconstriction // Am. Rev. Resp. Dis.— 1988.— Vol. 137, N 6.—P. 1309— 1311.
19. Wooley М., Anderson S. D., Quigley В. M. Duration of protectie effect of terbutaline sulfate and cromolyne sodium alone and in combination on exercise-unduced asthma // Chest.— 1990.— Vol. 97, N 1.— P. 39—45.
Review
For citations:
Tsoy A.N., Gaurilenko L.H., Titova E.V. The profilactic action of Ditec airsoles on bronchial constriction caused by physical exertion. PULMONOLOGIYA. 1993;(1):62-65. (In Russ.)