The role of sleep in pathogenesis of nocturnal asthma
Abstract
9 patients, 7 male and 2 female, aged from 20 to 65 years with nocturnal asthma (NA) were submitted to standart polysomnography in computerized sleep laboratory. Results of the study revealed that in patient group with Na in comparison with controls bronchoconstriction was more greater expressed. The sleep study showed the efficiency decrease of sleep with increased number of interventing wakefulness and drowsiness. Either the decrease or the absence of slow-wave sleep in some patients was observed. Alfa-delta intrusion and paroxismal activity were revealed with EEG. Patient respiration with NA was characterized by the presence of intermitting pereiods of hypoand hyperventilation. During REM and NR EM sleep, asthmatic attacks appeared. Obstructive apnea and hypopnea were often revealed in investigated patients. During the mentioned events, desaturation was not severe usually.
About the Authors
A. M. Belov
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
I. M. Madaeva
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
V. Z. Maman
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
References
1. Bellia V., Cuttitta G., Insalaco G. et al. Relationship of nocturnal bronchoconstriction to sleep stage // Am. Rev. Respir. Dis.— 1989.— Vol. 140, N 2.— ' P. 363—367.
2. Carskadon M. A., Brown E. D., Dement W. C. Sleep fragmentation in the elderly: Relationship to daytime sleep tendency // Neurobiol. Aging.— 1982.— Vol. 3.— P. 321—327.
3. Catterall J. R., Douglas N. J., Calverley P. M. et al. Irregular breathing and hypoxaemia during sleep in chronic stable asthma // Lancet.— 1982.— Vol. 1.— P. 301—304.
4. Catterall J. R., Rhind G. B., Stewart I. C. et al. Effect of sleep deprivation in overnight bronchoconstriction in nocturnal asthma // Thorax.— 1986.— Vol. 41.— P. 676— 680.
5. Chuchalin A. G., Mamyan V. Z. Features of sleep-disordered breathing in bronchial asthma patients // World Congress on Sleep Apnea and Rhonchopathy, 3-rd.— Tokyo, 1991.— P. A. 010.
6. Clark T. J. H., Hetzel M. R. Diurnal variation of asthma // Br. J. Dis. Chest.— 1977.— Vol. 71.— P. 87—92.
7. Connolly С. K. The effect of bronchodilators on diurnal rhythms in airway obstruction // Ibid.— 1981.— Vol. 75.— P. 197—203.
8. Douglas N. J., White D. P., Pickett С. K. et al. Respiration during sleep in normal man // Thorax.— 1982.— Vol. 37.— P. 840—844.
9. Fitzpatrick M. F.t Engleman H., Whyte K. F. et al. Morbidity in nocturnal asthma: sleep quality and daytime congnitive performance // Ibid.— 1991.— Vol. 46, N S.Р. 569—573.
10. Hetzel M. R., Clark T. J. H. Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate // Ibid.— 1980.— Vol. 35.— P. 732—738.
11. Kales A., Beall G. N., Bajor G. F. et al. Sleep studies in asthmatic adults: Relationship of attacks to sleep stage and time of night // J. Allergy.— 1968.— Vol. 41.— P. 164—173.
12. Montplaisir J., Walsh J., Malo J. L. Nocturnal asthma features of attacks, sleep and breathing patterns // Am. Rev. Respir. Dis.— 1982.— Vol. 125.— P. 18—22.
13. Morgan A. D., Rhind G. B., Connaughton J. J. et al. Breathing and oxygenation during sleep in patients with nocturnal asthma // Thorax.— 1987.— Vol. 42.— P. 600— 603.
14. Ravenscroft К., Hartn^c^n^n, E. L. The temporal correlation of nocturnal asthmatic attacks and the D-state // Psychophysiology.-— 1968.— Vol. 4.— P. 396—397.
15. Ssotea C. -A., Costello J., Ijaduela O. et al. Nocturnal and morning asthma // Thorax.— 1997.— Vol. 30.— P. 436—440.
16. Stepasski E, Salava W, Lamphete J. et al. Experimental sleep fragmentation and sleepiness in normal subjects: A preliminary report // Sleep Res.— 1984.— Vol. 13.— P. 193.
17. Tabarhsik E., Mullet N. L., Levisos H. et al. Chest wall mechanics and patterns of breathing during sleep in asthmatic adolescents // Am. Rev. Respir. Dis.— 1981.— Vol. 124.— P. 269—273.
18. T etset-Watwirk M. Nosturnal asthma: a study in general practice // J. R. Coll. Gen. Pract.— 1989.— Vol. 39, N 323.— P. 239—243.
19. Whyte K. F., Douglas N. J. Posture and nocturnal asthma // Thorax.— 1989.—Vol. 44, N 7.— P. 579—581.
Review
For citations:
Belov A.M., Madaeva I.M., Maman V.Z. The role of sleep in pathogenesis of nocturnal asthma. PULMONOLOGIYA. 1993;(1):16-23. (In Russ.)
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