The haptoglobin effect on haemoglobin mediated decomposition of hydrogen peroxide yielding free radicals
Abstract
The effect of haptoglobin on H2O2 dependent chemiluminescence (ChL) of native and modified with H2O2 or HOCl haemoglobin was studied. It was shown that haptoglobin decreases the native haemoglobin ChL intensity and the number of radicals formed during the reaction of haemoglobin with H2O2. It was supposed that the effect of haptoglobin is conditioned primarily by the haemoglobin catalytic activity decrease through Hp—Hg complex formation. It was shown that haptoglobin inhibits effectively H202-dependent ChL of both native and preincubated with H2O2 or HOCL haemoglobin.
About the Authors
E. V. Brukhanova
Российский государственный медицинский университет
Russian Federation
Russian Federation
A. N. Osipov
Российский государственный медицинский университет
Russian Federation
Russian Federation
Y. A. Vladimirov
Российский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Brukhanova E.V., Osipov A.N., Vladimirov Y.A. The haptoglobin effect on haemoglobin mediated decomposition of hydrogen peroxide yielding free radicals. PULMONOLOGIYA. 1995;(1):56-59. (In Russ.)
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